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Specifically, the study examined the impact of NFESEPG on blood pressure, oxidative stress markers, NO concentration, angiotensin\u2010converting enzyme (ACE) and arginase activities, and cardiac biomarkers in hypertensive rats. The study involved collecting, identifying, and processing the PG plant to obtain the ethanolic seed extract. The extract was then partitioned with solvents to isolate the n\u2010hexane fraction. Hypertension was induced in rats by oral administration of L\u2010NAME\u00a0for 10 days, while concurrent treatment with NFESEPG at two doses (200 and 400\u2009mg\/kg\/day) was administered orally. Blood pressure was measured using a noninvasive tail\u2010cuff method, and various biochemical parameters were assessed. Treatment with both doses of NFESEPG significantly reduced systolic and diastolic blood pressure in L\u2010NAME\u2010induced\u00a0hypertensive rats. Additionally, NFESEPG administration increased NO concentration and decreased ACE and arginase activities, malondialdehyde (MDA) levels, and cardiac biomarkers in hypertensive rats. The findings indicate that NFESEPG effectively lowered blood pressure in hypertensive rats induced by L\u2010NAME,\u00a0potentially through mechanisms involving the modulation of oxidative stress, NO bioavailability, and cardiac biomarkers. These results suggest the therapeutic potential of NFESEPG in managing hypertension and related cardiovascular complications.<\/jats:p>","DOI":"10.1002\/cbf.4095","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:34:15Z","timestamp":1721003655000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of n\u2010hexane fraction of <i>Piper guineense seed extract<\/i>\u00a0on N<sup>\u03c9<\/sup>\u2010nitro\u2010L\u2010arginine methyl ester hydrochloride\u2010induced hypertension in rats"],"prefix":"10.1002","volume":"42","author":[{"given":"Elijah Oluwatosin","family":"Olopade","sequence":"first","affiliation":[{"name":"Department of Biochemistry Adeleke University Ede Ede Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetoun Elizabeth","family":"Morakinyo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Adeleke University Ede Ede Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-2070","authenticated-orcid":false,"given":"Jude Oluwapelumi","family":"Alao","sequence":"additional","affiliation":[{"name":"School of Public Health and Interdisciplinary Studies Auckland University of Technology Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope A.","family":"Oyedepo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Adeleke University Ede Ede Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.17576\/jsm-2018-4710-18"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1139"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1221438"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020281"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318063"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707262"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.978378"},{"key":"e_1_2_9_10_1","first-page":"384","article-title":"Some edible spices of southeastern Nigeria with antiparasitic properties: a review","volume":"1","author":"Opara MN","year":"2014","journal-title":"Am J Ethnomed"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.12.072"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390210903534988"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.JPBS_175_19"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2017.03.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05814"},{"key":"e_1_2_9_16_1","unstructured":"HemmadiV. 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