{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:09:12Z","timestamp":1780326552584,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Treatment with melatonin is routinely prescribed for its potent antioxidant and cognitive\u2010promoting effects, nevertheless, it has yet to find neuromodulatory effects in normal and disease conditions. Therefore, to investigate its neuromodulatory mechanisms, melatonin was systemically administered over 10 consecutive days to both intracortical normal saline\u2010 and amyloid\u2010\u03b2 1\u201042 (A\u03b2) peptide\u2010injected rats. At the behavioral level, treatment with melatonin was associated with reduced efficacy in restoring A\u03b2\u2010induced deficit in passive\u2010avoidance memory. Whole\u2010cell patch\u2010clamp recordings from CA1 pyramidal neurons revealed that melatonin treatment reduced spontaneous and evoked intrinsic excitability in control rats while exerting a reduction of spontaneous, but not evoked activity, in the A\u03b2\u2010injected group. Interestingly, treatment with melatonin enhances after\u2010hyperpolarization in control, but not A\u03b2\u2010injected rats. In contrast, our voltage\u2010clamp study showed that Ih current is significantly enhanced by A\u03b2 injection, and this effect is further strengthened by treatment with melatonin in A\u03b2\u2010injected rats. Finally, we discovered that the transcription of melatonin receptors 1 (<jats:italic>MT1<\/jats:italic>) and 2 (<jats:italic>MT2<\/jats:italic>) is significantly upregulated in the hippocampi of A\u03b2\u2010injected rats. Collectively, our study demonstrates that systemic treatment with melatonin has differential neuromodulation on CA1 neuronal excitability, at least in part, via differential effects on after\u2010hyperpolarization and Ih currents due to A\u03b2\u2010induced neurotoxicity.<\/jats:p>","DOI":"10.1002\/cbf.4129","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:14:12Z","timestamp":1727676852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deregulation of Melatonin Receptors and Differential Modulation of After\u2010Hyperpolarization and Ih Currents Using Melatonin Treatment Due to Amyloid\u2010\u03b2\u2010Induced Neurotoxicity in the Hippocampus"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-3386","authenticated-orcid":false,"given":"Mohammad J.","family":"Eslamizade","sequence":"first","affiliation":[{"name":"Medical Nanotechnology 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