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The liver of rats treated with alloxan was characterized by hydropic dystrophy and lymphocytic infiltrations. Treatment with alloxan increased serum \u03b3\u2010GT and ALAT activities. The liver structure of rats treated with PPC did not differ from the liver of control animals. PPC normalized the biochemical abnormalities caused by the diabetes. The number of pancreatic islets and \u03b2\/\u03b1; cell ratio decreased in the diabetic rats. A number of \u03b2\u2010cells in this group did not contain granules. PPC prevented the decrease in the number of islets and the \u03b2\/\u03b1; cell ratio in the pancreas of the diabetic rats. The intensity of staining of \u03b2\u2010cell granules in the pancreas of PPC\u2010treated rats had a position intermediate between the control and diabetic groups. Alloxan increased the blood glucose content where treatment with PPC decreased this. The results suggest that PPC acts as a cytoprotector in the liver and pancreas of rats with experimental diabetes induced by alloxan.<\/jats:p>","DOI":"10.1002\/cbf.657","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T11:08:29Z","timestamp":1117278509000},"page":"131-137","source":"Crossref","is-referenced-by-count":14,"title":["Hepatic and pancreatic effects of polyenoylphosphatidylcholine in rats with alloxan\u2010induced diabetes"],"prefix":"10.1002","volume":"14","author":[{"given":"Vyacheslav","family":"Buko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana","family":"Lukivskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily","family":"Nikitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Tarasov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Zavodnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Borodinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronislava","family":"Gorenshtein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Janz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Josef","family":"Gundermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,12,4]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"279","volume-title":"Morphological Diagnosis in Liver Diseases","author":"Shaff Z.","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1986.10720125"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(80)90004-1"},{"issue":"2","key":"e_1_2_1_5_2","first-page":"49","article-title":"Molecular mechanisms of hepatoprotective action of prostaglandins in alcoholic liver injury","volume":"29","author":"Buko V. 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