{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:03:34Z","timestamp":1788246214433,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cancer is the second leading cause of death worldwide and is considered a major public health problem. Despite the significant advances in cancer research, the conventional cancer treatment approaches often lead to serious side effects that affect the quality of life of cancer patients. Thus, searching for new alternatives for cancer treatment is crucial to minimize these problems. Chalcone\u2010sulfonamide hybrids display a range of biological activities and have been widely investigated for their anticancer potential, being considered promising molecules for cancer treatment. This systematic review aimed to summarize the information available in the literature about the anticancer potential of chalcones\u2010sulfonamides in vitro and in vivo and their mechanisms of action. Our analysis demonstrated that chalcones\u2010sulfonamides have relevant cytotoxic potential against different cancer cell lines in vitro, especially against the human colorectal carcinoma cell line HCT\u2010116. These molecules have also reduced tumor growth in vivo. Some chalcones\u2010sulfonamides had improved cytotoxicity after chemical modification and could become more selective or even more potent than reference chemotherapeutics. The mechanisms underlying these effects demonstrated that chalcones\u2010sulfonamides may lead to cell death by different pathways, predominantly via apoptosis or necroptosis. This review may encourage researchers to advance studies with chalcones\u2010sulfonamides, especially to elucidate their mechanisms of action, contributing to the development of new alternatives to cancer treatment.<\/jats:p>","DOI":"10.1002\/cbf.70001","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T03:14:42Z","timestamp":1729307682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Uncovering the Potential of Chalcone\u2010Sulfonamide Hybrids: A Systematic Review on Their Anticancer Activity and Mechanisms of Action"],"prefix":"10.1002","volume":"42","author":[{"given":"J\u00e9ssica Maria Teles","family":"Souza","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie Aguiar de Negreiros Matos","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Barbosa da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio dos Santos","family":"Machado","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-6159","authenticated-orcid":false,"given":"Jos\u00e9 Delano Barreto","family":"Marinho Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-7097","authenticated-orcid":false,"given":"Ana J\u00e9rsia","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Cultura de C\u00e9lulas do Delta (LCCDelta) Universidade Federal do Delta do Parna\u00edba Parna\u00edba Piau\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_2_10_3_1","unstructured":"\u201cGlobal Cancer Burden Growing Amidst Mounting Need for Services \u201d World Health Organization 2024 https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101294"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2019.151165"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.04.015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-019-09967-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab155"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03777-w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2023.24.2.683"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.100977"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666211213092121"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.140"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.592654"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113837"},{"key":"e_1_2_10_18_1","first-page":"565","article-title":"Synthesis and Anticancer Activity Assay of Novel Chalcone\u2010Sulfonamide Derivatives","volume":"16","author":"Bonakdar A. C. S.","year":"2017","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.11.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcmed.2021.12.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.05.015"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdc.2022.100975"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.01.036"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.013"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2022.05.019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111115"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012589"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5935\/0103-5053.20150341"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ05612B"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2138551"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137063"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-2009-37"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-021-04818-w"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2017.11.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NJ03523C"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.05.034"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.09.019"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c07285"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.06.016"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.07.059"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.01.003"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2291336"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0012-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.04.045"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:45:39Z","timestamp":1760298339000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/cbf.70001"],"URL":"https:\/\/doi.org\/10.1002\/cbf.70001","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}