{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:39:04Z","timestamp":1790116744023,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The biosynthesis of silver nanoparticles (AgNPs) using cyanobacteria has gained significant attention due to its cost\u2010effective and eco\u2010friendly advantages in green synthesis. Additionally, biogenic AgNPs show great potential for biological applications, particularly in combating infections caused by drug\u2010resistant bacteria and fungi. This study synthesized using the cyanobacterium\n                    <jats:italic>Oscillatoria salina<\/jats:italic>\n                    (\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs). The\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs were characterized by a UV\u2010vis spectral absorption peak at 447\u2009nm, and their functional groups were identified through X\u2010ray diffraction analysis, revealing a crystal structure with a 2\u03b8 value of 38\u00b0. Transmission electron microscopy (TEM) analysis showed an average nanoparticle size of 9.81\u2009nm. The\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs demonstrated remarkable antioxidant, antibacterial, and antifungal properties. Their antibacterial activity was tested against multidrug\u2010resistant (MDR) Gram\u2010positive bacteria, including\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    , and\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    , as well as Gram\u2010negative bacteria such as\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    , and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , all isolated from clinical samples. The inhibition zones for bacterial strains ranged from 15 to 20\u2009mm, as measured by the agar\u2010well diffusion method. Similarly, the\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs exhibited antifungal activity, with 20\u201330\u2009mm inhibition zones against pathogenic fungi\n                    <jats:italic>Trichophyton rubrum<\/jats:italic>\n                    and\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    . Additionally, the antiproliferative effects of the\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs were evaluated on human cancer cell lines, including HeLa (cervical adenocarcinoma) and MD\u2010AMB\u2010231 (breast adenocarcinoma). In vivo toxicity studies were conducted using Swiss mouse models to assess the cytotoxic effects. Overall, the results suggest that\n                    <jats:italic>Os<\/jats:italic>\n                    \u2010AgNPs, biosynthesized using\n                    <jats:italic>O. salina<\/jats:italic>\n                    , hold promise as potential antimicrobial and anticancer agents for pharmaceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70043","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T08:47:16Z","timestamp":1737708436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biogenic Synthesis and Characterization of Silver Nanoparticles With Cyanobacterium\n                    <i>Oscillatoria salina<\/i>\n                    Using Against MDR Pathogenic Bacteria and Their Antiproliferative and Toxicity Study"],"prefix":"10.1002","volume":"43","author":[{"given":"Ajit Kumar","family":"Bishoyi","sequence":"first","affiliation":[{"name":"Central Research Laboratory, Institute of Medical Sciences and Sum Hospital Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar India"},{"name":"Department of Clinical Hematology, Institute of Medical Sciences and Sum Hospital Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmayee Priyadarsani","family":"Mandhata","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Institute of Medical Sciences and Sum Hospital Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chita Ranjan","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Institute of Medical Sciences and Sum Hospital Siksha \u2018O\u2019 Anusandhan Deemed to be University Bhubaneswar 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