{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:49:25Z","timestamp":1785354565655,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neuroinflammation generally refers to an inflammatory response within the central nervous system caused by various pathological insults, including infection, trauma, ischemia, and toxins. As the brain's sentinel immune cell, microglia are tasked as the first responders to infection or tissue injury and initiating an inflammatory response. The perennial shrub plant\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    L. was reported to possess anti\u2010inflammatory, anticancer, anti\u2010nociceptive, antidiabetic, neuroprotective, and antioxidative properties. The present study aimed to investigate the effects of\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    ethanolic extracts on the lipopolysaccharide (LPS)\u2010induced neuroinflammation model of BV\u20102 cells in comparison to carnosol and carnosic acid, phenolic diterpenes of the plant. Ultrasound\u2010assisted extraction was used to have ethanolic extract of the plant. LPS was used to induce inflammation in BV\u20102 cells. Tumor necrosis alpha (TNF\u2010\u03b1), interleukin 1 beta (IL\u20101\u03b2) secretion, reactive oxygen species (ROS) production, GSH\/GSSG ratio, protein carbonyl level, and caspase\u20103 activity were evaluated. Inflammation induced by LPS was reduced by the ethanolic extract. Both carnosol and carnosic acid decreased the TNF\u2010\u03b1 and IL\u20101\u03b2 levels as well. The ethanolic extract reduced ROS production and protein carbonylation, and increased GSH\/GSSG ratio more effectively compared to the effects of carnosol and carnosic acid. Results depicted that caspase\u20103 activity was reduced by the ethanolic extract and this effect was more pronounced compared to carnosol and carnosic acid. The present study indicates the ethanolic extract of\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    rescues BV\u20102 cells from apoptosis via alleviating inflammation and oxidative stress.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70073","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T01:53:16Z","timestamp":1744422796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Rosmarinus officinalis<\/i>\n                    Ethanolic Extracts Rescues BV\u20102 Cells via Modulating Inflammation and Redox Balance: Comparative Study With Carnosol and Carnosic Acid"],"prefix":"10.1002","volume":"43","author":[{"given":"Hatice","family":"Ors","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Medical Pharmacology Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Alimogullari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Aslan Erdem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacognosy Ankara University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubeyir","family":"Elmazoglu","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology Ankara Medipol University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-606X","authenticated-orcid":false,"given":"Asli F.","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Pharmacology Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00221-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115938"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00427"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02325-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105744"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0227-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03645-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2038"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175481"},{"key":"e_1_2_9_13_1","volume-title":"Neural Stem Cells and Therapy","author":"Carreira B. P.","year":"2012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00889-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081633"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2680409"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2020.45269.10541"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.03.052"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6894"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2017.02.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020290"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms130911027"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8030076"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.02.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900301"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500473834"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11223106"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.08.043"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020545"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13426"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.19080\/jpcr.2016.01.555556"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121212"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.04.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02227-3"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbf.70073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:58:03Z","timestamp":1771239483000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/cbf.70073"],"URL":"https:\/\/doi.org\/10.1002\/cbf.70073","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70073"}}