{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:26:39Z","timestamp":1760315199554,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cisplatin (CIS) is a chemotherapeutic agent known for nephrotoxicity through oxidative stress. Cancer treatment is also associated with psychological stress. Repeated exposure to social\u2010single prolonged stress (social\u2010SPS) modulates long\u2010term renal oxidative damage and apoptosis in a sex\u2010dependent manner in rats treated with cisplatin (CIS), despite mannitol's nephroprotective effects. We investigated whether repeated exposure to social\u2010single prolonged stress (social\u2010SPS) modulates long\u2010term renal oxidative damage and apoptosis in male and female rats treated with CIS and mannitol. Male and female Wistar rats were divided into three groups: control, CIS + mannitol, and CIS + mannitol + social\u2010SPS. Mannitol was administered 1\u2009h before CIS (2\u2009mg\/kg\/day, i.p., for 5 days). Social\u2010SPS was applied at three time points. At postnatal day 68, blood and kidney samples were collected for biochemical and Western blot analyses. Plasma renal biomarkers remained unchanged across groups. However, social\u2010SPS increased renal lipid peroxidation (TBARS) and protein oxidation (carbonyl content) in both sexes. CIS+social\u2010SPS decreased catalase activity and altered SOD, GST, and NPSH in a sex\u2010dependent manner. Only female rats showed increased renal BAX\/Bcl2 ratio, indicating apoptosis. In males, Na\u207a\/K\u207a\u2010K\u2010ATPase activity correlated positively with NPSH content. Despite mannitol nephroprotection, social stress exacerbated renal oxidative stress. Female rats were more susceptible to apoptosis, suggesting sex\u2010specific vulnerability to combined CIS and stress exposure. These findings highlight the importance of considering psychological stress and sex as modulators of chemotherapeutic toxicity and may inform future strategies for personalized cancer care.<\/jats:p>","DOI":"10.1002\/cbf.70101","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:29:58Z","timestamp":1751959798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Renal Oxidative Stress Despite Mannitol Nephroprotection: The Impact of <i>Social<\/i>\u2010Single Prolonged Stress in Male and Female Rats Exposed to Cisplatin"],"prefix":"10.1002","volume":"43","author":[{"given":"Juliano Ten Kathen","family":"Jung","sequence":"first","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Pregardier","family":"Klann","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Cruz Weber","family":"Fulco","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Angonesi","family":"Zborowski","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilson","family":"Zeni","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-3632","authenticated-orcid":false,"given":"Cristina Wayne","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences Federal University of Santa Maria Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S131316"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12860\/jnp.2014.26"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2010.09.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.673515"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2021.08.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2012.665542"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/CBF.3277"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2013.863322"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711432575"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ECOENV.2007.11.012"},{"key":"e_1_2_10_12_1","unstructured":"Z.Selamoglu N.\u00d6mer andH.\u00dcniversitesiGeneral Approaches to the Stem Cell Therapy in Diabetes Mellitus as Innovative Researches;2018 https:\/\/www.researchgate.net\/publication\/323365742."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13318-017-0436-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"B.Cruz Weber Fulco J.Ten Kathen Jung P.Maria Chagas S.Gon\u00e7alves Rosa V.Costa Prado andC.Wayne NogueiraDiphenyl diselenide is as effective as Ebselen in a juvenile rat model of cisplatin\u2010induced nephrotoxicity. 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