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However, current platelet storage methods at 22\u2009\u00b1\u20092\u00b0C face significant limitations, including a short shelf life (5\u20137 days), high risk of bacterial contamination, and progressive accumulation of metabolites such as lactic acid during prolonged storage. These issues impair transfusion efficacy and severely restrict the clinical utility of platelets. In contrast, cold storage at 4\u00b0C offers potential advantages: it extends platelet shelf life, reduces bacterial contamination risks, minimizes metabolite accumulation, and better preserves platelet hemostatic function. Mitochondria, as essential organelles in platelets, are central to energy metabolism, activation, adenosine triphosphate production, and regulation of cellular processes. They are of great significance for maintaining platelet physiological function and biological activity. This review examines the role of mitochondria in refrigerated platelet storage, focusing on their impact on energy metabolism, apoptosis, and post\u2010transfusion clearance. Additionally, we discuss mitochondrial\u2010targeted intervention strategies and future research directions to optimize platelet storage methods and enhance clinical transfusion outcomes.<\/jats:p>","DOI":"10.1002\/cbf.70104","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:45:02Z","timestamp":1753335902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role and Research Progress of Mitochondria in Long\u2010Term Cold\u2010Stored Platelets"],"prefix":"10.1002","volume":"43","author":[{"given":"Yujiao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, Beijing Jishuitan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-6625","authenticated-orcid":false,"given":"Shadamu","family":"Yusuying","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-1889","authenticated-orcid":false,"given":"Dongjiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Beijing Jishuitan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Translational Medicine R&amp;D Center Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"21","key":"e_1_2_10_2_1","first-page":"2629","article-title":"A Mechanism of Platelet Integrin \u03b1IIb\u03b23 Outside\u2010In Signaling Through a Novel Integrin \u03b1IIb Subunit\u2010Filamin\u2010Actin Linkage","volume":"141","author":"Liu J.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1786387"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16096"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1973.tb05442.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001547"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199512000-00006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16200"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022593"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533735"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16176130832.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000608"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000843"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020310"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02561-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021453"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279865"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1967917"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2018.12.013"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"184","article-title":"Influence of Taxol on the Response of Platelets to Chilling","volume":"108","author":"White J. 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