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Numerous studies have ascertained that the protective effect of olive oil on the heart is mainly attributed to its active component, oleuropein (OLE); however, the mechanism remains unknown. We hypothesised that OLE provides cardioprotective effects against cardiac hypertrophy through the alleviation of endoplasmic reticulum stress. In the present study, different dosage regimens (10, 30 and 60\u2009mg\/kg) of OLE were intragastrically administered to an isoproterenol (ISO) (7.5\u2009mg\/kg)\u2010induced cardiac hypertrophy mouse model. OLE alleviates ISO\u2010induced cardiac hypertrophy and apoptosis. In addition, the increased expression of endoplasmic reticulum (ER) stress\u2010related genes, such as Glucose\u2010Regulated Protein 78 (GRP78), activating transcription factor 4 (ATF4), CCAAT\/enhancer\u2010binding protein homologous protein (CHOP), and protein kinase RNA\u2010like ER kinase (PERK), was blunted by OLE, with reduced Sirtuin\u20101 (SIRT1) levels. Furthermore, after pretreatment with EX527 (a SIRT1 inhibitor), the anti\u2010hypertrophic, anti\u2010apoptosis and ER stress effects of OLE were diminished, implying a key role of SIRT1 in ER stress inhibition. Our study indicates that OLE ameliorates ISO\u2010induced cardiac hypertrophy through SIRT1 activation via ER stress inhibition.<\/jats:p>","DOI":"10.1002\/cbf.70122","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:11:01Z","timestamp":1758708661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oleuropein Ameliorates Isoproterenol\u2010Induced Cardiac Hypertrophy Through Sirtuin\u20101 Activation via Endoplasmic Reticulum Stress Inhibition"],"prefix":"10.1002","volume":"43","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Cardiovascular Medicine, Chongqing Emergency Medical Center Chongqing University Central Hospital Chongqing 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