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In this study, we report that in the absence of any changes in hepatic lactate dehydrogenase activity, the cardiac glycogen level fluctuates following short\u2010term binge drinking. The change in cardiac glycogen levels follows a sex specific pattern. Our work is first to demonstrate that early metabolic changes in the heart, specifically glycogen levels, can be an ideal readout for forthcoming hepatic and systemic complications following binge drinking at an earlier stage. Also, females demonstrate a robust change in cardiac glycogen levels in comparison to their binge drinking male counterparts following short\u2010term exposure, hinting at an early cardiometabolic risk in females. This study prompts us to look at early metabolic changes in the heart as a marker for binge drinking\u2010mediated injury.<\/jats:p>","DOI":"10.1002\/cbf.70135","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:02:01Z","timestamp":1761721321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Glycogen Fluctuations Are Robust in Short\u2010Term Than Long\u2010Term Binge Drinking and Follows a Sex Specific Manner"],"prefix":"10.1002","volume":"43","author":[{"given":"Victoria","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Graduate Studies Midwestern University Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katlyn","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Graduate Studies Midwestern University Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rafferty","sequence":"additional","affiliation":[{"name":"Chicago College of Osteopathic Medicine Midwestern University Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorab","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Graduate Studies Midwestern University Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanth","family":"Puthanveetil","sequence":"additional","affiliation":[{"name":"Chicago College of Osteopathic Medicine Midwestern University Downers Grove Illinois USA"},{"name":"Department of Pharmacology, College of Graduate Studies Midwestern University Downers Grove Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cResults From the 2019 National Survey on Drug Use and Health: Detailed Tables \u201d Substance Abuse and Mental Health Services Administration (SAMHSA) 2020."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/REM-23-0005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.518.2008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660069"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01614.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00081.2015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.107"},{"issue":"300","key":"e_1_2_9_9_1","first-page":"81","article-title":"Criteria for Diagnosis of Cardiomyopathy in Patients With Alcoholic Liver Cirrhosis Before the Onset of Heart Damage Clinical Signs","author":"Abrahamovych M.","year":"2020","journal-title":"Georgian Medical News"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"23","article-title":"Treatment of Heart Failure and Ascites With Ultrafiltration in Patients With Intractable Alcoholic Cardiomyopathy","volume":"44","author":"Bilora F.","year":"2002","journal-title":"Panminerva Medica"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(03)00004-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020572"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00101-X"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210310001602176"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"148","article-title":"Alcohol and Inflammation: A Possible Mechanism for Protection Against Ischemic Heart Disease","volume":"12","author":"Stewart S. 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