{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:06:18Z","timestamp":1782518778711,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functions, it is well established that AD is associated with cardiovascular risk factors beyond only cerebral decline. In this study, we measured hemodynamic parameters related to cardiovascular and cerebrovascular function in 5xFAD mice with AD and their littermates. Specifically, we measured cardiovascular pulse wave velocity parameters, a marker of arterial stiffness and cardiovascular risk, and cerebrovascular pulse wave velocity, a novel technique to measure cerebral arterial stiffness. Our results showed that while 5xFAD mice exhibited significant differences in ejection time, pulse pressure, and Tei index, many other cardiovascular and cerebral parameters were not different. Despite reports that amyloid plaque deposition begins at an early age of 1.5 months in 5xFAD mice, our results did not indicate significant cardiovascular changes. Studies to elucidate cardiovascular and cerebrovascular parametric changes should be done at later ages where the underlying changes are more profound.<\/jats:p>","DOI":"10.1002\/cbf.70138","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T06:33:52Z","timestamp":1762842832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alterations in Cardiovascular Parameters in 5xFAD Murine Model"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-4478","authenticated-orcid":false,"given":"Andrea G.","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"},{"name":"Department of Life and Physical Sciences Fisk University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Neikirk","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-5831","authenticated-orcid":false,"given":"Sepiso K.","family":"Masenga","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"},{"name":"Department of Cardiovascular Science and Metabolic Diseases Livingstone Center for Prevention and Translational Science Livingstone Southern Province Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryanna","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zer","family":"Vue","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Garza\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estev\u00e3o","family":"Scudese","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"},{"name":"Laboratory of Biosciences of Human Motricity (LABIMH) of the Federal University of State of Rio de Janeiro (UNIRIO)  Rio de Janeiro Brazil"},{"name":"Sport Sciences and Exercise Laboratory (LaCEE) Catholic University of Petr\u00f3polis (UCP) Petr\u00f3polis Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Damo","sequence":"additional","affiliation":[{"name":"Department of Life and Physical Sciences Fisk University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Taffet","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-5579","authenticated-orcid":false,"given":"Okwute M.","family":"Ochayi","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Sciences, College of Medicine and Health Science, Baze University Abuja Federal Capital Territory Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah M.","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernat","family":"Exil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology St. Louis University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton","family":"Oliver","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Immunobiology, Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Sharma","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute for Infection Immunology and Inflammation, Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Gaye","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Science and Metabolic Diseases Livingstone Center for Prevention and Translational Science Livingstone Southern Province Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanel","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briar","family":"Tomeau","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaCara","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markis\u2032","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-3724","authenticated-orcid":false,"given":"Taneisha","family":"Gillyard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Railyn","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Prakash","sequence":"additional","affiliation":[{"name":"The Center for AIDS Health Disparities Research (P.P., R.C., G.M., M.B., C.D.), Meharry, Medical College Nashville Tennessee USA"},{"name":"Department of Microbiology Immunology, and Physiology (P.P., R.C., G.M., M.B., C.D.), Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanilah","family":"Frierson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandravanu","family":"Dash","sequence":"additional","affiliation":[{"name":"The Center for AIDS Health Disparities Research (P.P., R.C., G.M., M.B., C.D.), Meharry, Medical College Nashville Tennessee USA"},{"name":"Department of Microbiology Immunology, and Physiology (P.P., R.C., G.M., M.B., C.D.), Meharry Medical College Nashville Tennessee USA"},{"name":"Department of Biochemistry Cancer Biology, Pharmacology and Neuroscience (P.P., R.C. G.M., M.B., C.D.), Meharry Medical College Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mungai","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Vanderbilt Center for Immunobiology, Vanderbilt University Nashville Tennessee USA"},{"name":"Vanderbilt Institute for Infection Immunology and Inflammation, Vanderbilt University Nashville Tennessee USA"},{"name":"Vanderbilt Institute for Global Health Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Gaddy","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology, and Immunology, Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Medicine Division of Infectious Diseases, Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Medicine Health, and Society, Vanderbilt University Nashville Tennessee USA"},{"name":"Department of Veterans Affairs Tennessee Valley Health Systems Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9063-0324","authenticated-orcid":false,"given":"Nelson","family":"Wandira","sequence":"additional","affiliation":[{"name":"Department of Public Health School of Health Sciences Busoga University Iganga Iganga Eastern Region Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-952X","authenticated-orcid":false,"suffix":"Jr.","given":"Antentor","family":"Hinton","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anilkumar K.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Hospital Houston Texas USA"},{"name":"Department of Medicine Baylor College of Medicine Houston Texas USA"},{"name":"Indus Instruments Webster Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2020.88482"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01124-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0524-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00340-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.336869"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa114"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190474"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.14.53"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.713726"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26713-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-2"},{"issue":"03","key":"e_1_2_10_13_1","article-title":"Cardiovascular Hemodynamics in Mice With Tumor Necrosis Factor Receptor\u2014Associated Factor 2 Mediated Cytoprotection in the Heart","volume":"09","author":"Marshall A. G.","year":"2022","journal-title":"bioRxiv"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.855709"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168644"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00004.2003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt055"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070646"},{"key":"e_1_2_10_19_1","volume-title":"Engineering Design of the Cardiovascular System of Mammals","author":"Dawson T. H.","year":"1991"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.850538"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2125"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22387"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2025.100983"},{"key":"e_1_2_10_25_1","unstructured":"T. D.Homan S.Bordes andE.Cichowski \u201cPhysiology Pulse Pressure \u201dhttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482408\/."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000060127.96986.F4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S34874"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-067951"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011045"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.86.2.513"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2013.22.2.84"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T03:53:20Z","timestamp":1766030000000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cbf.70138"],"URL":"https:\/\/doi.org\/10.1002\/cbf.70138","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70138"}}