{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:49:08Z","timestamp":1790124548809,"version":"4.0.1"},"reference-count":85,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cadmium exposure is a known disruptor of ovarian redox homeostasis and steroidogenesis, with clinically relevant implications for fertility and pregnancy outcomes. We hypothesized that date seed extract (DS), rich in antioxidant constituents, and low\u2010dose gamma radiation (LDR) could synergistically counteract Cd\u2010induced ovarian toxicity. (1) To assess whether DS and\/or low\u2010dose \u03b3\u2010radiation mitigate Cd\u2010induced oxidative stress, inflammatory signaling, and impairment of steroidogenesis; (2) to determine whether the combination of DS\u2009+\u2009LDR offers superior protection relative to single treatments; and (3) to evaluate whether biochemical improvements translate to preservation of ovarian histology. The present study highlights the combinatorial approach (DS\u2009+\u2009LDR) as a potential, novel intervention for reducing Cd\u2010associated gonadotoxicity. Forty\u2010eight female Swiss albino rats were allocated to eight groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096): Control; DS; R; DS\u2009+\u2009R; Cd; Cd\u2009+\u2009DS; Cd\u2009+\u2009R; Cd\u2009+\u2009DS\u2009+\u2009R. Treatments were administered for 21 days (DS) and 2 weeks (Cd exposure) with ongoing \u03b3\u2010radiation where indicated. Outcomes included: (i) oxidative stress markers (SOD, GSH); (ii) steroidogenic axis components (StAR, CYP11A1, 3\u03b2\u2010HSD, 17\u03b2\u2010HSD) at the ovarian level; (iii) hormonal profiles (e.g., estrogen, progesterone, and relevant gonadotropins); (iv) inflammatory signaling (NF\u2010\u03ba\u03b2); and (v) histopathology of ovarian sections. Cd exposure caused a significant decline in ovarian antioxidants (SOD, GSH) and a reduction in steroidogenic enzyme expression, accompanied by hormonal disturbances and prominent NF\u2010\u03ba\u03b2\u2013driven inflammatory changes. Histologically, Cd induced cortical and follicular disruption with increased degenerative changes. DS and LDR mitigated these effects, with the combination DS\u2009+\u2009LDR showing the most robust rescue: antioxidant defenses and steroidogenic enzyme expression nearly normalized, hormonal levels stabilized, NF\u2010\u03ba\u03b2 signaling reduced, and ovarian architecture preserved. Statistical significance was achieved for most endpoints (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and trends supported additive or synergistic benefits for DS\u2009+\u2009LDR. The combination of DS and low\u2010dose \u03b3\u2010radiation offers superior protection against Cd\u2010induced ovarian toxicity by restoring redox balance, downregulating inflammatory pathways, normalizing steroidogenesis, and preserving ovarian histology. These findings support further exploration of DS\u2009+\u2009R as a potential therapeutic strategy to mitigate heavy metal\u2013related reproductive damage.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70162","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:15:22Z","timestamp":1769670922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ameliorative Role of\n                    <i>Phoenix dactylifera<\/i>\n                    Seeds Against Cadmium\u2010Induced Ovarian Toxicity in Rats: The Role of Low\u2010Dose Gamma Radiation"],"prefix":"10.1002","volume":"44","author":[{"given":"Azza E.","family":"Kayed","sequence":"first","affiliation":[{"name":"Radiation Biology Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermeen M.","family":"Elbakary","sequence":"additional","affiliation":[{"name":"Radiation Biology Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa A.","family":"Hagag","sequence":"additional","affiliation":[{"name":"Radiation Biology Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah A.","family":"Gabr","sequence":"additional","affiliation":[{"name":"Biological Applications Department, Nuclear Research Center Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-0009","authenticated-orcid":false,"given":"Monda M. M.","family":"Badawy","sequence":"additional","affiliation":[{"name":"Health Radiation Research Department, National Center for Radiation Research and Technology Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010036"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11040354"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/pac-2016-0910"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12403-020-00349-6"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14249-y"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-022-00431-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy12081952"},{"issue":"3","key":"e_1_2_14_9_1","first-page":"63","article-title":"The Role of Cadmium in the Pathogenesis of Kidney Diseases: A Review","volume":"8","author":"Genchi G.","year":"2023","journal-title":"Toxics"},{"issue":"3","key":"e_1_2_14_10_1","first-page":"135","article-title":"Cadmium Toxicity and Treatment: An Update","volume":"8","author":"Rahimzadeh M. 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