{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:25:01Z","timestamp":1780046701366,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emerging evidence suggests a link between gut microbiota dysbiosis and osteoporosis. However, specific bacterial taxa and metabolic correlates in human osteoporosis remain poorly characterized. This study explored gut microbial profiles and serum biochemical markers in osteoporosis patients compared to non\u2010osteoporosis individuals in Hainan, China. Fecal samples and serum biochemistry, including liver function, kidney function, lipid profiles, and ion concentrations, were analyzed in six osteoporosis patients and six non\u2010osteoporosis individuals. Gut microbiota composition was assessed via 16S rDNA gene sequencing. Differential abundance analysis and linear discriminant analysis effect size (LEfSe) were performed to identify biomarkers. Osteoporosis patients exhibited significantly higher serum sodium levels (143.31\u2009\u00b1\u20091.40\u2009mmol\/L vs. 140.00\u2009\u00b1\u20092.60\u2009mmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and reduced HDL cholesterol (1.03\u2009\u00b1\u20090.14 vs. 1.33\u2009\u00b1\u20090.09\u2009mmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Microbiota profiling revealed 11 enriched and seven depleted bacteria in patients by LEfSe analysis. Notably,\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    showed the highest relative abundance increase in osteoporosis patients, while\n                    <jats:italic>Megamonas<\/jats:italic>\n                    abundance was significantly reduced as indicated by square root of the indicator value (sqrtIVt). This pilot study identifies elevated serum sodium and gut\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    enrichment as potential metabolic and microbial signatures of osteoporosis in the Hainan population. These findings suggest that modulation of gut microbiota and sodium management could be explored as preventive strategies. Larger, multiethnic cohorts and mechanistic studies are needed to validate these biomarkers and elucidate causality.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70207","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:58:27Z","timestamp":1775192307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Sodium and Gut\n                    <i>Klebsiella<\/i>\n                    Are Positively Related to Osteoporosis"],"prefix":"10.1002","volume":"44","author":[{"given":"Xiuhong","family":"Cao","sequence":"first","affiliation":[{"name":"Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"},{"name":"NHC Key Laboratory of Tropical Disease Control, Engineering Research Center for Hainan Bio\u2010Smart Materials and Bio\u2010Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, School of Life Sciences and Medical Technology Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbing","family":"Hua","sequence":"additional","affiliation":[{"name":"Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"},{"name":"Department of Emergency Surgery, Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Emergency Surgery, Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-6299","authenticated-orcid":false,"given":"Fabiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"},{"name":"NHC Key Laboratory of Tropical Disease Control, Engineering Research Center for Hainan Bio\u2010Smart Materials and Bio\u2010Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, School of Life Sciences and Medical Technology Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-6770","authenticated-orcid":false,"given":"Tongmeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital Hainan Medical University Haikou China"},{"name":"NHC Key Laboratory of Tropical Disease Control, Engineering Research Center for Hainan Bio\u2010Smart Materials and Bio\u2010Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, School of Life Sciences and Medical Technology Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2025-0031"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxaf279"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20240041"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.70719"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2024.11.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8588"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.08.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18830-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15020395"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.01.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/jomb-2015-0003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3450"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0061-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1373013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103168"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-023-02927-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01733-20"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65150-0"}],"container-title":["Cell 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