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The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous\u2010diffuse (CDL) forms, to the potentially fatal systemic visceral leishmaniasis (VL). Neurological manifestations are not generally considered as classical clinical signs or symptoms of leishmaniasis, but in this review, we present evidence that this is a false assumption. We examine brain involvement in human and canine leishmaniasis and the contribution of animal models for studying cerebral\n                    <jats:italic>Leishmania<\/jats:italic>\n                    infection. Clinical descriptions of brain involvement are presented, and evidence of\n                    <jats:italic>Leishmania<\/jats:italic>\n                    invasion of the central nervous system. Notably, evidence for brain involvement comes from considerable studies in the dog and covers aspects of disruption of the blood\u2010brain and blood\u2010cerebrospinal fluid barriers and the nature of the inflammatory response.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70209","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:20:02Z","timestamp":1775910002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Involvement in Leishmaniasis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-215X","authenticated-orcid":false,"given":"Camila S.","family":"Freitas","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais, Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6681-9014","authenticated-orcid":false,"given":"Eduardo A. 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