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On the other hand, excess load of cholesterol in systemic compartments, for example, blood vessels, and intracellular or intraorganellar rooms may end up with serious detrimental consequences, namely, heart attack, diabetes, carcinogenesis, and organ or organelle storage disorders. With this view, cholesterol is a biotic handler of both bright and dark edges. Since its discovery, cholesterol has been sequeled with differential challenges of the life process, either advantageous or disadvantageous. Advantageous features are associated with essential physiological processes, and disadvantageous attributes are the marks of metabolic malfunctioning from the incidents cropped up either by its overuse or from multifactorial circumstantial interferences, for example, carcinogens, obesity, inflammation, therapeutic side effects, and so on.<\/jats:p>","DOI":"10.1002\/cbf.70227","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:55:52Z","timestamp":1778655352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol and Its Journey Over the Centuries (1769\u22122025): The Highlights and Challenges"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9082-4076","authenticated-orcid":false,"given":"Koshankan","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Birla Institute of Technology and Science, Pilani, Hyderabad Campus Jawahar Nagar, Kapra Mandal Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-6998","authenticated-orcid":false,"given":"Nimai Chand","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Health Sciences SGT University Budhera Gurugram Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.2.439S"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr087"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M074997"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000113291.39267.0a"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-1981(00)00140-2"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.01.005"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117575"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300402200"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8362242"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.04.014"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(90)90490-c"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00804-9"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2019.05.001"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.37349\/ent.2021.00011"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.560266"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","unstructured":"W. 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