{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T16:33:51Z","timestamp":1784392431494,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp; Function"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Phenolic acids, abundant in plant\u2010based foods, are increasingly investigated for their anticancer potential. This study systematically evaluated the cytotoxic effects of three hydroxycinnamic acids\u2014trans\u2010cinnamic acid (tCA), p\u2010coumaric acid (pCA), and ferulic acid (FA)\u2014across 10 cancer cell lines (A\u2010673, HeLa, PC\u20103, SW48, HT\u201029, Caco\u20102, HUH\u20107, MG\u201063, 2A3, CARM\u2010L12\u2010TG3) and one non\u2010cancerous cell line (Phoenix) after 48 and 72\u2009h of treatment. IC\n                    <jats:sub>50<\/jats:sub>\n                    values were determined via MTT assay. At 48\u2009h, tCA showed the most significant reduction in metabolic activity in Caco\u20102 and HUH\u20107 cells, while HT\u201029 was the most resistant. pCA showed selective potency in A\u2010673 and PC\u20103 cells, whereas FA demonstrated broad cytotoxic activity, with pronounced effects in SW48 and HeLa cells. Cytotoxicity increased in a time\u2010dependent manner at 72\u2009h. The non\u2010cancerous Phoenix cells were generally less sensitive, supporting the selective inhibitory effect of these compounds toward malignant cells. Statistical analyses revealed highly significant effects of treatment and time factors, with significant treatment and time interactions in A\u2010673, HeLa, and PC\u20103 cells. These findings indicate that pCA is the most selective compound, FA exerts the broadest cytotoxicity, and tCA shows a balanced but time\u2010dependent effect. Collectively, this study highlights hydroxycinnamic acids as promising scaffolds for developing selective anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70241","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:06:22Z","timestamp":1780898782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential Cytotoxicity of Hydroxycinnamic Acids in Cancer Cells: Structure\u2013Activity Insights From a Broad Panel of Cell Lines"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-5728","authenticated-orcid":false,"given":"Kadriye Asl\u0131han","family":"Onat Ta\u015fdelen","sequence":"first","affiliation":[{"name":"Graduate School of Natural and Applied Science, Biology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-2912","authenticated-orcid":false,"given":"Merve","family":"Sezer K\u00fcrk\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (ALM Research Building) Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"},{"name":"Research and Application Center for Research Laboratories (ALM Research Building) Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0401","authenticated-orcid":false,"given":"Hatice","family":"\u00d6zt\u00fcrkel Kabaka\u015f","sequence":"additional","affiliation":[{"name":"Graduate School of Natural and Applied Science, Biology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-3366","authenticated-orcid":false,"given":"Anara","family":"Babayeva","sequence":"additional","affiliation":[{"name":"Graduate School of Natural and Applied Science, Biology Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8997-4116","authenticated-orcid":false,"given":"Bekir","family":"\u00c7\u00f6l","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center (ALM Research Building) Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"},{"name":"Biology Department, Faculty of Science Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University  Mu\u011fla T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164724"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9020163"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.22271\/phyto.2024.v13.i1a.14811"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-024-10631-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S345870"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00336"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/je900154x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00018A"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03191384"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-024-04642-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00073-1"},{"key":"e_1_2_11_13_1","first-page":"2571","article-title":"Antiproliferative and Proapoptotic Activities of Ferulic Acid in Breast and Liver Cancer Cell Lines","volume":"18","author":"ElKhazendar M.","year":"2019","journal-title":"Tropical Journal of Pharmaceutical Research"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3689-3"},{"key":"e_1_2_11_15_1","first-page":"136","article-title":"Cytotoxic Effects of Trans\u2010Cinnamaldehyde From Cinnamomum Osmophloeum Leaves on Human Cancer Cell Lines","volume":"2","author":"Fang S.\u2010H.","year":"2004","journal-title":"International Journal of Applied Science and Engineering"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500014"},{"key":"e_1_2_11_17_1","first-page":"3","article-title":"Ferulic Acid\u2014A Comprehensive Pharmacology of an Important Bioflavonoid","volume":"3","author":"Gohil K. J.","year":"2012","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191219292"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2010.03.027"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.558414"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504013X13685487925095"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0246-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7726"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2016.1252919"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13931"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620319"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(99)00167-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.727"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/compounds4040044"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.09.044"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-31"},{"key":"e_1_2_11_32_1","first-page":"12","article-title":"Discovery, Optimization, and Cellular Activities of 2\u2010(Aroylamino)cinnamamide Derivatives Against Colon Cancer Cells","volume":"2019","author":"Omar A. M.","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-023-03841-8"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.21597\/jist.885898"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.18038\/estubtda.1327658"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-013-9205-3"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452572"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003940050016"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4581"},{"key":"e_1_2_11_40_1","first-page":"4019","article-title":"Plant Phenolics Ferulic Acid and P\u2010Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation Through EGFR Down\u2010Regulation","volume":"17","author":"Roy N.","year":"2016","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.215S"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.28979\/jarnas.1645815"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-025-04506-4"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8700-2"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.06.001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-0210-8"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5937326"},{"key":"e_1_2_11_48_1","first-page":"633","article-title":"Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines","volume":"9","author":"Sova M.","year":"2013","journal-title":"Medicinal Chemistry (Los Angeles)"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52143-y"},{"key":"e_1_2_11_50_1","first-page":"968","article-title":"Ferulic Acid Inhibits Proliferation and Promotes Apoptosis via Blockage of PI3K\/Akt Pathway in Osteosarcoma Cell","volume":"8","author":"Wang T.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.09.001"},{"key":"e_1_2_11_52_1","first-page":"1075","article-title":"Metabolic Pathways of Cinnamic Acid Derivatives in Brazilian Green Propolis in Rats","volume":"86","author":"Yamaga M.","year":"2022","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513000688"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.08.034"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5041"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbf.70241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.70241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:21:45Z","timestamp":1782458505000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.70241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cbf.70241"],"URL":"https:\/\/doi.org\/10.1002\/cbf.70241","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70241"}}