{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:30:21Z","timestamp":1790872221164,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012494","name":"Chongqing Municipal Education Commission Foundation","doi-asserted-by":"publisher","award":["HZ2021006"],"award-info":[{"award-number":["HZ2021006"]}],"id":[{"id":"10.13039\/100012494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sustained low\u2010grade inflammation is increasingly recognized as a central element in how polycystic ovary syndrome (PCOS) develops. Here we set out to clarify what role follicular fluid (FF)\u2010borne exosomal miR\u2010424\u20105p plays in shaping ovarian inflammation and how this ties in with the ovulatory problems seen in PCOS. Across FF samples taken from patients, miR\u2010424\u20105p levels tracked inversely with pro\u2010inflammatory cytokine concentrations to a striking degree. When granulosa cells (GCs) were challenged with lipopolysaccharide (LPS), delivering exosomal miR\u2010424\u20105p dampened cytokine release and restored the expression of ovulation\u2010linked genes. Using a dual\u2010luciferase reporter assay, we traced this effect to FGF2, which miR\u2010424\u20105p binds directly, and we found FGF2\/FGFR1 signaling to be conspicuously raised in PCOS. In dehydroepiandrosterone (DHEA)\u2010treated rats modeling the syndrome, giving exosomal miR\u2010424\u20105p eased ovarian inflammation and brought back part of the lost ovulatory capacity. Taken together, the data suggest that exosomal miR\u2010424\u20105p tempers ovarian inflammation in PCOS by holding the FGF2\/FGFR1 axis in check, which casts fresh light on the follicular abnormalities that mark this condition.<\/jats:p>","DOI":"10.1002\/cbf.70248","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:51:53Z","timestamp":1782921113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exosomal MicroRNA\u2010424\u20105p From Polycystic Ovary Syndrome Follicular Fluid Attenuates Ovarian Inflammation via Targeting the Fibroblast Growth Factor 2\/Fibroblast Growth Factor Receptor 1 Axis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1730-6275","authenticated-orcid":false,"given":"Dong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Chongqing 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