{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:59:00Z","timestamp":1785218340215,"version":"3.55.0"},"reference-count":89,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Persistent organic pollutants such as organochlorine pesticides (OCPs) have been implicated in obesity and metabolic dysfunction. As they bioaccumulate in adipose tissue, OCPs may act as obesogens, but in vivo evidence for aldrin, endosulfan and lindane is limited. This study investigated whether subacute exposure to aldrin, endosulfan and lindane elicits obesogenic effects in male rats by examining weight gain, serum biochemistry and metabolic and inflammatory gene expression in white adipose tissue (WAT) and brown adipose tissue (BAT). Thirty\u2010two adult male Sprague\u2010Dawley rats were randomly assigned to receive corn oil (control) or oral aldrin, endosulfan or lindane (1\u2009mg\/kg every other day for 28 days). Body weight was recorded weekly. Serum liver enzymes and lipid profile were determined. In WAT and BAT, we quantified mRNA expression of thermogenic and adipogenic markers (\n                    <jats:italic>Pparg<\/jats:italic>\n                    ,\n                    <jats:italic>Ucp1<\/jats:italic>\n                    ,\n                    <jats:italic>Ucp3<\/jats:italic>\n                    ,\n                    <jats:italic>Fndc5<\/jats:italic>\n                    ), and the pro\u2010 and anti\u2010inflammatory cytokines (\n                    <jats:italic>Il\u20101b<\/jats:italic>\n                    ,\n                    <jats:italic>Tnf\u2010\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>Il\u201010<\/jats:italic>\n                    ,\n                    <jats:italic>Il\u20104<\/jats:italic>\n                    ). Lindane caused significant weight gain from the first week (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), whereas aldrin and endosulfan increased body weight only at week four (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Endosulfan\u2010treated rats had reduced total and high\u2010density lipoprotein cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) without changes in low\u2010density lipoprotein cholesterol, very\u2010low\u2010density lipoprotein cholesterol, or triglycerides. In WAT,\n                    <jats:italic>Pparg<\/jats:italic>\n                    ,\n                    <jats:italic>Ucp1<\/jats:italic>\n                    , and\n                    <jats:italic>Fndc5<\/jats:italic>\n                    transcripts were unchanged, while\n                    <jats:italic>Ucp3<\/jats:italic>\n                    tended to decrease in the endosulfan group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.056). In BAT, endosulfan increased\n                    <jats:italic>Ucp1<\/jats:italic>\n                    and decreased\n                    <jats:italic>Fndc5<\/jats:italic>\n                    levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with no changes in\n                    <jats:italic>Pparg<\/jats:italic>\n                    or\n                    <jats:italic>Ucp3<\/jats:italic>\n                    . Endosulfan suppressed\n                    <jats:italic>Il\u20101b<\/jats:italic>\n                    ,\n                    <jats:italic>Tnf\u2010\u03b1<\/jats:italic>\n                    , and\n                    <jats:italic>Il\u201010<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) transcripts in both WAT and BAT, and all pesticides reduced\n                    <jats:italic>Il\u20104<\/jats:italic>\n                    expression in BAT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Overall, short\u2010term exposure to aldrin, endosulfan or lindane interfered with metabolic and inflammatory pathways in a compound\u2010specific manner, with lindane causing early weight gain and endosulfan eliciting complex effects on lipid metabolism and adipose gene expression. We suggest that even short\u2010term exposure to OCPs may affect metabolic regulation in male rats, with each chemical exerting distinct effects.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70262","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:17:32Z","timestamp":1784287052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subacute Exposure to Aldrin, Endosulfan and Lindane Differentially Alters Metabolic and Inflammatory Gene Expression in White and Brown Adipose Tissue of Male Rats"],"prefix":"10.1002","volume":"44","author":[{"given":"Nada Abdelhamid Mohamed","family":"Boujanah","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Yeditepe University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan Suleyman","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Yeditepe University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Sumer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Experimental Research Center Yeditepe University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Yakin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Yeditepe University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-6535","authenticated-orcid":false,"given":"Bayram","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology Dokuz Eylul University  Izmir T\u00fcrkiye"},{"name":"Izmir Biomedicine and Genome Center  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2199853"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42362-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-023-00495-3"},{"key":"e_1_2_11_7_1","unstructured":"Organization W. 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