{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:59:01Z","timestamp":1785218341257,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE13\u20100032\u201001"],"award-info":[{"award-number":["ANR\u201021\u2010CE13\u20100032\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR; PJT\u2010203841"],"award-info":[{"award-number":["CIHR; PJT\u2010203841"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A mutation of the\n                    <jats:italic>ADAM20<\/jats:italic>\n                    gene was described in an infertile patient whose spermatozoa were observed accumulating in the perivitelline space of oocytes. To decipher its role in the fertilization process, we produced a mouse model knock\u2010out (KO) for the\n                    <jats:italic>Adam20<\/jats:italic>\n                    gene. Surprisingly,\n                    <jats:italic>Adam20<\/jats:italic>\n                    \u2010KO males showed an in vivo fertility similar to their wild\u2010type littermates and had normal sperm counts and morphology. However, they presented a reduced fertility in in vitro fertilization assays. To explore the hypothesis that the two flanking genes\n                    <jats:italic>Adam25<\/jats:italic>\n                    and\n                    <jats:italic>Adam39<\/jats:italic>\n                    could compensate the lack of\n                    <jats:italic>Adam20<\/jats:italic>\n                    given their very high homology, we produced a triple KO deleting these three neighbor genes simultaneously. The phenotype was strictly identical to that of the single gene deletion. Therefore, ADAM20, ADAM25, and ADAM39 are not essential proteins for fertilization in mice but they seem to participate modestly to the process.\n                    <jats:italic>Adam20<\/jats:italic>\n                    \u2010KO males are fertile in vivo but have a reduced fertility in vitro. Males deleted for three neighbor and very homologous genes (\n                    <jats:italic>Adam20<\/jats:italic>\n                    ,\n                    <jats:italic>Adam25<\/jats:italic>\n                    , and\n                    <jats:italic>Adam39<\/jats:italic>\n                    ) have the same phenotype as the simple\n                    <jats:italic>Adam20<\/jats:italic>\n                    \u2010KO. These genes are dispensable for normal fertility but contribute modestly to fertilization.\n                  <\/jats:p>","DOI":"10.1002\/cbf.70265","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:50:14Z","timestamp":1784105414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ADAM20 Participates Modestly to Fertilization as Its Absence Leads to In Vitro Hypofertility in Mouse"],"prefix":"10.1002","volume":"44","author":[{"given":"Marie\u2010Sophie","family":"Girault","sequence":"first","affiliation":[{"name":"Institut Cochin, INSERM, CNRS Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM, CNRS Universit\u00e9 Paris Cit\u00e9 Paris 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