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Epigenetic mechanisms, including DNA methylation, histone modifications, non\u2010coding RNAs (ncRNAs), and RNA modifications, provide one route through which environmental and cellular signals reshape bone\u2010cell function. This review summarizes current evidence linking epigenetic regulation to osteoblasts, osteoclasts, and osteocytes; distinguishes human, animal, and in vitro evidence; and evaluates the translational maturity of proposed biomarkers and therapies. DNA methylation and histone modifications have strong mechanistic support in bone\u2010cell differentiation models, whereas ncRNA and N6\u2010methyladenosine (m6A) pathways are expanding rapidly but remain largely preclinical. Blood\u2010based methylation or RNA signatures and epigenetic therapies are promising but should be considered exploratory until validated in prospective cohorts, fracture\u2010related endpoints, and bone\u2010cell\u2010specific intervention studies.<\/jats:p>","DOI":"10.1002\/cbf.70293","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:49:07Z","timestamp":1787726947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects"],"prefix":"10.1002","volume":"44","author":[{"given":"Minjuan","family":"Du","sequence":"first","affiliation":[{"name":"School of Health and Wellbeing University of Glasgow Glasgow 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