{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:58:15Z","timestamp":1790582295563,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771972"],"award-info":[{"award-number":["31771972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Previous transcriptomic analysis revealed that eicosapentaenoic acid (EPA) alters miRNA expression in HepG2 cells. Two key miRNA\u2010mRNA axes mediating EPA's antioxidant effects were identified. EPA was found to downregulate let\u20107c\u20103p, which directly targets mitochondrial transcription factor A (TFAM). Inhibiting let\u20107c\u20103p or overexpressing TFAM enhanced antioxidant capacity, reduced reactive oxygen species, improved mitochondrial function, and promoted mitochondrial biogenesis. In parallel, EPA was found to upregulate miR\u201034c\u20105p, which directly targets NAD\u2010Dependent Protein Deacetylase Sirtuin (SIRT1). This repression of SIRT1 is associated with increased activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. These findings indicate a dual\u2010miRNA mechanism through which EPA alleviates oxidative stress via coordinated enhancement of mitochondrial biogenesis and enzymatic defenses.<\/jats:p>","DOI":"10.1002\/cbf.70298","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:29:48Z","timestamp":1788863388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual miRNA\u2010Mediated Axes Act in Concert in the Antioxidant Action of Eicosapentaenoic Acid: let\u20107c\u20103p\/TFAM Drives Mitochondrial Biogenesis While miR\u201034c\u20105p\/SIRT1 Potentiates Enzymatic Defenses"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0631-5172","authenticated-orcid":false,"given":"Haiqi","family":"Wang","sequence":"first","affiliation":[{"name":"College of Ocean Food and Biological Engineering Jimei University Xiamen China"},{"name":"Fujian Marine Functional Food 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