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Emerging evidence highlights the critical role of epigenetic regulation in this process. Dysregulation of histone post\u2010translational modifications (HPTMs) is increasingly recognized as a pivotal mechanism linking metabolic reprogramming to various pathological conditions. HPTMs constitute one of the key epigenetic regulatory mechanisms and mediate ferroptosis by modulating the transcription of core ferroptosis\u2010related genes. This review systematically summarizes site\u2010specific HPTMs, including histone methylation, acetylation, ubiquitination, phosphorylation, lactylation, and \u03b2\u2010hydroxybutyrylation. Furthermore, we elucidate how infectious diseases, tumors, and chronic non\u2010infectious conditions drive disease progression via HPTMs\u2010dependent regulation of ferroptosis. A comprehensive dissection of these epigenetic regulatory networks may facilitate the development of combinatorial therapeutic strategies targeting HPTMs and ferroptosis inducers, thereby providing new insights into the treatment of ferroptosis\u2010associated disorders.<\/jats:p>","DOI":"10.1002\/cbf.70300","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:30:26Z","timestamp":1788438626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone Post\u2010Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4410-990X","authenticated-orcid":false,"given":"Xiaoqian","family":"Tang","sequence":"first","affiliation":[{"name":"Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical College University of South China 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