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Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways. Disruption of the tightly coordinated wound\u2010healing cascade, together with aberrant protein signaling, mitochondrial dysfunction, antimicrobial resistance, sustained fibroblast activation, and maladaptive epigenetic reprogramming, drives pathological tissue repair culminating in chronic non\u2010healing wounds, including diabetic, ischemic, and venous ulcers, as well as fibrotic outcomes such as hypertrophic and keloid scarring. The persistent fibroblast activation, reduced apoptosis, prolonged TGF\u2010\u03b2 activity, and severe fibrosis induced by mechanical methods trigger excessive healing, while existing therapies fail to manage these functions. Therefore, in order to develop advancements toward precise and personalized medicine, it is important to understand the various mechanisms involved in wound healing. The current review provides a comprehensive understanding of various fundamental mechanisms involved in wound healing, such as cellular, molecular, signaling pathways, genetic, epigenetic, pathological, immunological, and systemic mechanisms. Knowledge of these mechanisms and how they work under physiological as well as pathological conditions connects to clinical inefficiency, which helps to provide accurate medicine. A deeper mechanistic knowledge paves the way for developing innovative biomaterials; nanotechnology\u2010based therapeutic strategies, specific drug delivery, molecular biomarkers, and scar\u2010free healing of wounds, which enrich the future with advanced therapeutics and personalized medicine for wounds.<\/jats:p>","DOI":"10.1002\/cbf.70309","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:15:54Z","timestamp":1789715754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Pathways of Wound Healing: From Hemostasis to Scar\u2010Free Regeneration"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0985-8344","authenticated-orcid":false,"given":"Devadass Jessy","family":"Mercy","sequence":"first","affiliation":[{"name":"Medical Bionanotechnology, Faculty of Allied and Healthcare Sciences, Chettinad Hospital &amp; Research Institute, Chettinad Academy of Research and Education, Kelambakkam Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-5241","authenticated-orcid":false,"given":"Koyeli","family":"Girigoswami","sequence":"additional","affiliation":[{"name":"Medical Bionanotechnology Lab, Department of Obstetrics and Gynecology Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Thandalam Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-2544","authenticated-orcid":false,"given":"Agnishwar","family":"Girigoswami","sequence":"additional","affiliation":[{"name":"Medical Bionanotechnology, Faculty of Allied and Healthcare Sciences, Chettinad Hospital &amp; Research Institute, Chettinad Academy of Research and Education, Kelambakkam Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092526"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5567"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21612"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15102"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58101395"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11060209"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00027162231198976"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70381"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2025-0039"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216321"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44337-025-00478-4"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq049"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13233-024-00291-5"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168048"},{"key":"e_1_2_19_16_1","volume-title":"Macrophages\u2014Molecular Pathways and Immunometabolic Processes","author":"Wani N. 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