{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:53Z","timestamp":1791284033693,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 32370177"],"award-info":[{"award-number":["NSFC 32370177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>AMP\u2010activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in cancer progression through lipid metabolism is dual\u2010edged. On the one hand, AMPK suppresses lipogenesis by inhibiting key regulators such as SREBP, ACC, and HMGCR, thereby limiting the biosynthetic substrates and membrane lipid availability required for tumor cell proliferation. On the other hand, AMPK activation may also enhance fatty acid oxidation and metabolic adaptation, which can support growth and survival under nutrient limitation, hypoxia, or therapeutic stress. This dual role presents therapeutic challenges but also creates opportunities for context\u2010specific intervention. In this review, we summarize the mechanisms by which AMPK regulates lipid metabolism in cancer and discuss the current progress, therapeutic potential, and limitations of AMPK\u2010modulating strategies.<\/jats:p>","DOI":"10.1002\/cbf.70314","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:18:56Z","timestamp":1791281936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AMPK\u2010Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies"],"prefix":"10.1002","volume":"44","author":[{"given":"Yuying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology, School of Basic Medicine Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-4308","authenticated-orcid":false,"given":"Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Basic Medicine Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-5958","authenticated-orcid":false,"given":"Bing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology, School of Basic Medicine Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"18","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1016\/j.molcel.2021.08.015","article-title":"AMPK: Restoring Metabolic Homeostasis over Space and Time","volume":"81","author":"Trefts E.","year":"2021","journal-title":"Molecular Cell"},{"issue":"7","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and Function of AMPK in Physiology and Diseases","volume":"48","author":"Jeon S. 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