{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:02:46Z","timestamp":1791187366767,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,4,6]],"date-time":"2001-04-06T00:00:00Z","timestamp":986515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possible use of a mouse monoclonal antibody directed against rat pancreatic B\u2010cell surface ganglioside(s) and labelled with radioactive iodine for selective imaging of the endocrine pancreas by a non\u2010invasive procedure was investigated by following its pancreatic fate in experiments conducted either <jats:italic>in vitro<\/jats:italic> by incubation of rat isolated pancreatic islets, acinar tissue and pancreatic pieces or <jats:italic>in vivo<\/jats:italic> after intravenous injection of the <jats:sup>125<\/jats:sup>I\u2010labelled antibodies ([<jats:sup>125<\/jats:sup>I]\u03b3\u2010G). Although the binding of [<jats:sup>125<\/jats:sup>I]\u03b3\u2010G per \u00b5g protein was about one order of magnitude higher in isolated islets than in acinar tissue, no significant difference was detected when comparing pancreatic pieces or isolated islets from control animals and rats rendered diabetic by one or two prior administrations of streptozotocin (STZ rats). Likewise, except in one set of experiments, no significant difference was found between control animals and STZ rats, when measuring the radioactive content of the pancreatic gland, relative to that of plasma, 1\u20134 days after the intravenous injection of [<jats:sup>125<\/jats:sup>I]\u03b3\u2010G. These findings indicate that under the present experimental conditions, the mouse monoclonal antibody labelled with radioactive iodine does not appear to be a promising tool for selective imaging of the endocrine pancreas, e.g. by single photon emission computerized tomography. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.903","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:13:04Z","timestamp":1030291984000},"page":"107-115","source":"Crossref","is-referenced-by-count":22,"title":["Pancreatic fate of a <sup>125<\/sup>I\u2010labelled mouse monoclonal antibody directed against pancreatic B\u2010cell surface ganglioside(s) in control and diabetic rats"],"prefix":"10.1002","volume":"19","author":[{"given":"Laurence","family":"Ladri\u0115re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Malaisse\u2010Lagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Alejandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy J.","family":"Malaisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,4,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111409"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)91322-0"},{"key":"e_1_2_1_4_2","first-page":"147","volume-title":"Methods in Diabetes Research","author":"Malaisse\u2010Lagae F","year":"1984"},{"key":"e_1_2_1_5_2","first-page":"43","article-title":"Pancreatic uptake of 65Zn in control and streptozotocin\u2010injected rats","volume":"28","author":"Ladri\u00e8re L","year":"2000","journal-title":"Med Sci Res"},{"key":"e_1_2_1_6_2","first-page":"1196","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer HU","year":"1974"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-116-3-1168"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400476"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0021-9258(17)33710-9","article-title":"The stimulus\u2010secretion coupling of glucose\u2010induced insulin release. XXL. Fasting\u2010induced adaptation of key glycolytic enzymes in isolated islets","volume":"251","author":"Malaisse WJ","year":"1976","journal-title":"J Biol Chem"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.903","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:17:14Z","timestamp":1760044634000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,6]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1002\/cbf.903"],"URL":"https:\/\/doi.org\/10.1002\/cbf.903","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,6]]}}}