{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:50:57Z","timestamp":1760061057592,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sexually\u2010transmitted diseases (STD) can facilitate the progression of HIV\u20101 infection. Among them, as we have previously demonstrated, cervico\u2010vaginal dysplasia\u2014papillomavirus (HPV)\u2010induced, together with HSV\u20102 co\u2010infection, seems to be correlated with a more evident immunodepression in HIV\u2010positive women, compared with other sexually transmitted diseases. Here we have analysed some of the main correlated markers of HIV\u20101 infection progression: CD4\u2009+ T lymphocyte concentration, CD4\u2009+\/CD8\u2009+ T cells ratio, HIV\u20101 RNA loads and haemoglobin (Hb) concentration in 30 HIV\u20101 positive women co\u2010infected with HPV, and suffering from cervico\u2010vaginal dysplasia, in different stages. In particular, we noticed a positive correlation, evaluated by Spearman's test, between the degree of progression of dysplastic stages (CIN1\u21923) until invasive carcinoma (IC) and HIV\u20101 RNA loads (<jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009+0.78; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and in contrast, a negative correlation between the same stages of progression and respectively CD4+ T cell concentration (<jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.54; <jats:italic>p<\/jats:italic>\u2009=\u20090.01), ratio (<jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2212\u20090.63; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and Hb concentration (<jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, it is important to underline that low levels of Hb generally paralleled the degree of immunodepression. In fact CD4\u2009+ T cell levels and ratio positively correlated with Hb concentrations respectively, with <jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009+0.83; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>C<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u2009+0.90; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001. Finally, the most efficacious antiretroviral combined therapy (HAART\u2009=\u2009Highly Active Antiretroviral Therapy) can improve the above described laboratory parameters in HIV\u20101\/HPV co\u2010infected women and seems to prevent the progression of CIN1 to the following stages of the dysplastic disease. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cbf.950","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T22:05:28Z","timestamp":1031695528000},"page":"233-236","source":"Crossref","is-referenced-by-count":1,"title":["Cervico\u2010vaginal dysplasia\u2014papillomavirus\u2010induced and HIV\u20101 infection: role of correlated markers for prognostic evaluation"],"prefix":"10.1002","volume":"20","author":[{"given":"A.","family":"Pugliese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Andronico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gennero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pagliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/315733"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199807010-00016"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.75.1.30"},{"key":"e_1_2_1_5_2","first-page":"32","article-title":"Sexually transmitted infections and cervico\u2010vaginal dysplasia in a cohort of HIV\u2010positive women in Turin","volume":"25","author":"Pugliese A","year":"2001","journal-title":"Cancer Detect Prev"},{"key":"e_1_2_1_6_2","first-page":"258","article-title":"Human herpesvirus 8 and associated diseases in a group of 67 HIV\u2010seropositive individuals","volume":"24","author":"Pugliese A","year":"2000","journal-title":"Cancer Detect Prev"},{"key":"e_1_2_1_7_2","first-page":"184","article-title":"Correlation between markers of iron metabolism and HIV\u20101 replication in HIV\u2010seropositive individuals and in HIV\u2010infected cells","volume":"2","author":"Gennero L","year":"1997","journal-title":"Ligand Assay"},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Immune cell functions in iron overload","volume":"75","author":"De Sousa M","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_9_2","first-page":"1630","volume-title":"Principles and Practice of Infectious Diseases","author":"Bonnez W","year":"2000"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5587"},{"key":"e_1_2_1_11_2","first-page":"179","article-title":"Cervical intraepithelial neoplasia in human immunodeficiency virus\u2010positive patients","volume":"24","author":"Ahr A","year":"2000","journal-title":"Cancer Detect Prev"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(93)90077-Z"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199902250-00019"},{"key":"e_1_2_1_14_2","first-page":"1962","article-title":"International AIDS\u2010Society USA. Antiretroviral therapy in HIV infection","volume":"227","year":"1997","journal-title":"JAMA"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:23:08Z","timestamp":1760041388000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/cbf.950"],"URL":"https:\/\/doi.org\/10.1002\/cbf.950","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"type":"print","value":"0263-6484"},{"type":"electronic","value":"1099-0844"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}