{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:38:46Z","timestamp":1789907926700,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,23]],"date-time":"2002-04-23T00:00:00Z","timestamp":1019520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cansin Medical, Turkey"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochemistry &amp;amp; Function"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lipid disorders and increased oxidative stress may exacerbate some complications of diabetes mellitus. Previous studies have implicated the beneficial effects of some antioxidants, omega\u20103 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the protection of cells from the destructive effect of increased lipids and lipid peroxidation products. This study, therefore, was designed to investigate the effects of cod liver oil (CLO, Lysi Ltd. Island), which comprises mainly vitamin A, PUFAs, EPA and DHA. Effects were monitored on plasma lipids, lipid peroxidation products (MDA) and the activities of antioxidant enzymes, glutathione peroxidase (GSHPx) and catalase in heart, liver, kidney and lung of non\u2010diabetic control and streptozotocin (STZ)\u2010induced\u2010diabetic rats. Two days after STZ\u2010injection (55\u2009mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    i.p.), non\u2010diabetic control and diabetic rats were divided randomly into two groups as untreated or treated with CLO (0.5\u2009ml\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    rat per day) for 12 weeks. Plasma glucose, triacylglycerol and cholesterol concentrations were significantly elevated in 12\u2010week untreated\u2010diabetic animals; CLO treatment almost completely prevented these abnormalities in triacylglycerol and cholesterol, but hyperglycaemia was partially controlled. CLO also provided better weight gain in diabetic animals. In untreated diabetic rats, MDA markedly increased in aorta, heart and liver but was not significantly changed in kidney and lung. This was accompanied by a significant increase in both GSHPx and catalase enzyme activities in aorta, heart, and liver of diabetic rats. In kidney and lung, diabetes resulted in reduced catalase while GSHPx was significantly activated. In aorta, heart, and liver, diabetes\u2010induced changes in MDA were entirely prevented by CLO treatment. In the tissues of CLO\u2010treated diabetic animals, GSHPx activity paralleled those of control animals. CLO treatment also caused significant improvements in catalase activities in every tissue of diabetic rats, but failed to affect MDA and antioxidant activity in control animals. The current study suggests that the treatment of diabetic rats with CLO provides better control of glucose and lipid metabolism, allows recovery of normal growth rate, prevents oxidative\/peroxidative stress and ameliorates endogenous antioxidant enzyme activities in various tissues. Because CLO contains a plethora of beneficial compounds together, its use for the management of diabetes\u2010induced complications may provide important advantages. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/cbf.977","type":"journal-article","created":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T08:53:03Z","timestamp":1036399983000},"page":"297-302","source":"Crossref","is-referenced-by-count":51,"title":["Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin\u2010diabetic rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Tu\u011fba","family":"H\u00fcnkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fugen","family":"Aktan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Ceylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7imen","family":"Karasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.4.405"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2560205"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0910441"},{"key":"e_1_2_1_5_2","first-page":"308","article-title":"Alpha\u2010lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin\u2010diabetes (The ADIC Study Group)","volume":"13","author":"Ko\u00e7ak G","year":"2000","journal-title":"Diabet Nutr Metab"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0461(2000)14:6<329::AID-JBT5>3.0.CO;2-G"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0461(2001)15:1<41::AID-JBT5>3.0.CO;2-Z"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227543"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00117-F"},{"key":"e_1_2_1_10_2","first-page":"577","article-title":"Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney","volume":"46","author":"Kedziora\u2010Kornatowska K","year":"1998","journal-title":"Biochem Mol Biol Int"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/food.19950390402"},{"key":"e_1_2_1_12_2","article-title":"Effects of vitamin A and insulin on antioxidative state of diabetic rat heart: a comparison study with combination treatment","volume":"19","author":"Zobal\u0131 F","year":"2001","journal-title":"Cell Biochem Funct"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240060"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.3.560s"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2000.0226"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1179\/rer.2000.5.1.45"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03311.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01056-J"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.11.1207"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114599001415"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.10.1620"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051499"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.207"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(87)90071-5"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00028-3"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109642"},{"key":"e_1_2_1_30_2","first-page":"251","article-title":"Antioxidative state of the myocardium and kidneys in acute diabetic rats","volume":"42","author":"Volkovova K","year":"1993","journal-title":"Physiol Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0733"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00468-8"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400086"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011000327529"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)00151-9"}],"container-title":["Cell Biochemistry and Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbf.977","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbf.977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:56:32Z","timestamp":1760057792000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/cbf.977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,23]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/cbf.977"],"URL":"https:\/\/doi.org\/10.1002\/cbf.977","archive":["Portico"],"relation":{},"ISSN":["0263-6484","1099-0844"],"issn-type":[{"value":"0263-6484","type":"print"},{"value":"1099-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,23]]}}}