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A randomized 12\u2010mer peptide library presented on M13 phages was screened for peptides with binding affinity for the mirror image of A\u03b2(1\u201342). After four rounds of selection and amplification the peptides were enriched with a dominating consensus sequence. The mirror image of the most representative peptide (\n                      <jats:sc>D<\/jats:sc>\n                      \u2010pep) was shown to bind A\u03b2(1\u201342) with a dissociation constant in the submicromolar range. Furthermore, in brain tissue sections derived from patients that suffered from Alzheimer's disease, amyloid plaques and leptomeningeal vessels containing A\u03b2 amyloid were stained specifically with a fluorescence\u2010labeled derivative of\n                      <jats:sc>D<\/jats:sc>\n                      \u2010pep. Fibrillar deposits derived from other amyloidosis were not labeled by\n                      <jats:sc>D<\/jats:sc>\n                      \u2010pep. Possible applications of this novel and highly specific A\u03b2 ligand in diagnosis and therapy of Alzheimer's disease are discussed.\n                    <\/jats:italic>\n                  <\/jats:p>","DOI":"10.1002\/cbic.200300631","type":"journal-article","created":{"date-parts":[[2003,7,30]],"date-time":"2003-07-30T06:15:48Z","timestamp":1059545748000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Selection of\n                    <scp>D<\/scp>\n                    \u2010Amino\u2010Acid Peptides That Bind to Alzheimer's Disease Amyloid Peptide A\u03b2\n                    <sub>1\u201342<\/sub>\n                    by Mirror Image Phage Display"],"prefix":"10.1002","volume":"4","author":[{"given":"Katja","family":"Wiesehan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Buder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold P.","family":"Linke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Patt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stoldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Willbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,28]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01508-7"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.293_1.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00029-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05408-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050470"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01232-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7609"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-j0004.2001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200201000-00004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/78482"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.4001944"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.9022"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.4937"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5257.1854"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00036a073"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(19990605)39:3<371::AID-NEU4>3.0.CO;2-E"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi982824n"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340160309"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(97)00004-7"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","unstructured":"S. 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