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When formamide is heated in the presence of montmorillonites, the efficient one\u2010pot synthesis of purine, adenine, cytosine, and uracil is obtained. Along with these nucleobases, several components of the inosine pathway are obtained: 5\u2010aminoimidazole\u20104\u2010carboxamide, 5\u2010formamidoimidazole\u20104\u2010carboxamide and hypoxanthine. This almost complete catalogue of nucleic acid precursors is accompanied by<\/jats:italic> N<jats:sup><jats:italic>9<\/jats:italic><\/jats:sup><jats:italic>\u2010formylpurine, which, containing a masked glycosidic bond in its formyl moiety, is a plausible precursor of purine acyclonucleosides. In addition, montmorillonites differentially affect the rate of degradation of nucleobases when embedded in 2\u2032\u2010deoxyoligonucleotides; namely, montmorillonites protect adenine and guanine from the degradative action of formamide, while thymine degradation is enhanced. The oligonucleotide backbone reactivity to formamide is also affected; this shows that the interaction with montmorillonites modifies the rate of abstraction of the H\u03b1 and H\u03b2 protons on the sugar moieties.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cbic.200400119","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T04:00:29Z","timestamp":1097640029000},"page":"1558-1566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Synthesis and Degradation of Nucleobases and Nucleic Acids by Formamide in the Presence of Montmorillonites"],"prefix":"10.1002","volume":"5","author":[{"given":"Raffaele","family":"Saladino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Crestini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ciambecchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Ciciriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Di Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"The Physical Basis of Life","author":"Bernal J. 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