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Recently, adenovirus type 37 (Ad37) was found to bind and infect human corneal cells through attachment to carbohydrate structures that carry terminal \u03b1\u2010(2\u20133)\u2010linked sialic acids. Herein we present a synthetic route to a 3\u2032\u2010sialyllactose derivative and corresponding multivalent HSA conjugates with varying orders of valency. The potential of these compounds as inhibitors of EKC\u2010causing adenovirus of serotype Ad37, was studied with both a binding assay and an infectivity assay. The results revealed that these compounds effectively prevent Ad37 from binding to and infecting human corneal epithelial (HCE) cells. Moreover, the inhibition is significantly increased with higher orders of multivalency.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cbic.200400227","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T05:50:46Z","timestamp":1106891446000},"page":"358-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Multivalent HSA Conjugates of 3\u2032\u2010Sialyllactose are Potent Inhibitors of Adenoviral Cell Attachment and Infection"],"prefix":"10.1002","volume":"6","author":[{"given":"Susanne M. 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