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Yeasts of the genus<\/jats:italic> Malassezia<jats:italic>, particularly<\/jats:italic> M. furfur<jats:italic>, a saprophyte occurring widely on human skin, are generally regarded as the causative agents.<\/jats:italic> M. furfur <jats:italic>is able to convert tryptophan into a variety of indole alkaloids, some of them showing biological properties that correlate well with certain clinical features of pityriasis versicolor. This suggests a possible role for these compounds in the pathophysiology of the disease. We here report that the novel pityriarubins A, B and C, isolated from cultures of the yeast, inhibit respiratory burst in human neutrophils, activated by various agents, in a highly selective, unexpected manner. The release of 5\u2010lipoxygenase products after challenge of neutrophils with the calcium ionophore A23187 is also inhibited in a dose\u2010dependent manner. These activities reflect the close structural relationship of pityriarubins to bisindolylmaleimides, which have recently gained great interest as protein kinase inhibitors.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cbic.200500163","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T04:17:16Z","timestamp":1130386636000},"page":"2290-2297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Pityriarubins, Novel Highly Selective Inhibitors of Respiratory Burst from Cultures of the Yeast <i>Malassezia furfur<\/i>: Comparison with the Bisindolylmaleimide Arcyriarubin A"],"prefix":"10.1002","volume":"6","author":[{"given":"Hans\u2010Joachim","family":"Kr\u00e4mer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute\u2010Christina","family":"Hipler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Irlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Hort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf\u2010Hasso","family":"B\u00f6deker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Steglich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mayser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,30]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00441.x"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00378.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.21-57.2002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb14843.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500459303"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00336.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00957.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0294-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026042903354"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00319-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400247"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200352549"},{"key":"e_1_2_6_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200352549"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200590118"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac198961030281"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6971-1_1"},{"key":"e_1_2_6_16_2","volume-title":"Studies in Natural Products Chemistry","author":"Gribble G. 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