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To this end, the behavior of several trifluoromethyl\u2010substituted oxanorbornadiene derivatives in the 1,3\u2010dipolar cycloaddition was studied and optimized to give a clean and efficient method for bio\u2010orthogonal ligation in an aqueous environment. After radioisotope treatment, the resulting <jats:sup>111<\/jats:sup>In\u2010labeled c(RGD)\u2010CF<jats:sub>3<\/jats:sub>\u2010triazole\u2010DTPA conjugate was subjected to preliminary biological evaluation and showed high affinity for \u03b1<jats:sub>v<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> (IC<jats:sub>50<\/jats:sub>=192 n<jats:sc>M<\/jats:sc>) and favorable pharmacokinetics.<\/jats:p>","DOI":"10.1002\/cbic.200800074","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T07:49:05Z","timestamp":1215762545000},"page":"1805-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Application of Metal\u2010Free Triazole Formation in the Synthesis of Cyclic RGD\u2013DTPA Conjugates"],"prefix":"10.1002","volume":"9","author":[{"given":"Sander S.","family":"van Berkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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