{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:19:53Z","timestamp":1791148793898,"version":"4.1.0"},"reference-count":167,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T00:00:00Z","timestamp":1271289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2010,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front\u2010line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV\u20101 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.<\/jats:italic><\/jats:p>","DOI":"10.1002\/cbic.200900779","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T12:33:42Z","timestamp":1271334822000},"page":"880-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":179,"title":["The Future of Aminoglycosides: The End or Renaissance?"],"prefix":"10.1002","volume":"11","author":[{"given":"Jacob L.","family":"Houghton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Garneau\u2010Tsodikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,27]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(97)01033-0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/327389a0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200700113"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.061903.155440"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200454217"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200454217"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10414"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300657"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00153-9"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01435-3"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2006.05.017"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00629-3"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki862"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01096-06"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp8112914"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9715105"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/1804"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1489-1496.2006"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5112-5118.2005"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)00028-9"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700271"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.430-450.2003"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2005.05.001"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja029736h"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(00)00615-6"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000095"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06657.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.06169.x"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600109"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja050918w"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.03.003"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm856"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00149-4"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00602-3"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.07.082"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700251"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/331280a0"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/b813252f"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.3.487"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2006.04.003"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0496-467"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1280"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20052"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05756"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200923030-00003"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm801640k"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1309"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.51.4.439-457.1987"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.38.100184.001321"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0301088"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.15.1.7"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.18.5.722"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3322-3327.2000"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.4.672-693.2000"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-007-9194-y"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2624"},{"key":"e_1_2_8_56_2","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1128\/AAC.43.12.2975","volume":"43","author":"Westbrock\u2010Wadman S.","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01050"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.19.5657-5664.2003"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.7.2274-2280.1997"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.491-496.2004"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1086\/313949"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2949-2953.2005"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh455"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07756.x"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3249-3256.2000"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907925106"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4897-3_4"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.727"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi060723g"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.638-645.2002"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4693-4702.2004"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1402-1409.2002"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00529-F"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2005.02595.x"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/20.6.803"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.52.809"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2238-2244.2001"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.20.6492-6498.1993"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108810200"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb830"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(99)80066-5"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81585-8"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/35030006"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/35030019"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.03.017"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi701957c"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi002736e"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(99)80006-4"},{"key":"e_1_2_8_89_2","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1016\/S0021-9258(18)90781-7","volume":"259","author":"Radika K.","year":"1984","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.0233503"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444905021487"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034148h"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi800664x"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1347"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.7.885"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211680200"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09302.x"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/28.3.333"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00251a021"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00188a024"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.25.483"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80274-3"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00062-09"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.4.641"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90063-0"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00039a026"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00121-9"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00149-09"},{"key":"e_1_2_8_109_2","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1016\/S0021-9258(17)34554-4","volume":"253","author":"Williams J. W.","year":"1978","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_110_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00041a005"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90501-3"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80370-X"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.01532.x"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2877-2884.2001"},{"key":"e_1_2_8_115_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1496-1502.2003"},{"key":"e_1_2_8_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.11.073"},{"key":"e_1_2_8_117_2","doi-asserted-by":"publisher","DOI":"10.1086\/515328"},{"key":"e_1_2_8_118_2","doi-asserted-by":"publisher","DOI":"10.1039\/B712690P"},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.08.053"},{"key":"e_1_2_8_120_2","first-page":"81","volume":"12","author":"Janknegt R.","year":"1990","journal-title":"Pharm. World Sci."},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.04.015"},{"key":"e_1_2_8_122_2","first-page":"15","volume":"3","author":"Tange R. A.","year":"1987","journal-title":"Ziekenhuisfarmacie"},{"key":"e_1_2_8_123_2","doi-asserted-by":"publisher","DOI":"10.1080\/14992020802215862"},{"key":"e_1_2_8_124_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-3565(24)35099-2","volume":"291","author":"Harvey S. C.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_8_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.08.009"},{"key":"e_1_2_8_126_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811258106"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn112"},{"key":"e_1_2_8_128_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.3.440"},{"key":"e_1_2_8_129_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1003"},{"key":"e_1_2_8_130_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-79"},{"key":"e_1_2_8_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)85051-X"},{"key":"e_1_2_8_132_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.30.893"},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.835"},{"key":"e_1_2_8_134_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.33.675"},{"key":"e_1_2_8_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2006.10.064"},{"key":"e_1_2_8_136_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9910356"},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01625a033"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.03.056"},{"key":"e_1_2_8_139_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol035213i"},{"key":"e_1_2_8_140_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.84.87"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.1080\/15257770008033010"},{"key":"e_1_2_8_142_2","doi-asserted-by":"publisher","DOI":"10.1039\/b501028d"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9612817"},{"key":"e_1_2_8_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)00339-9"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja000575w"},{"key":"e_1_2_8_146_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol701760k"},{"key":"e_1_2_8_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400197"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm061200"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00005-1"},{"key":"e_1_2_8_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.10.038"},{"key":"e_1_2_8_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(03)00156-6"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034766y"},{"key":"e_1_2_8_153_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900028n"},{"key":"e_1_2_8_154_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi701071h"},{"key":"e_1_2_8_155_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600569"},{"key":"e_1_2_8_156_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp594"},{"key":"e_1_2_8_157_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501399"},{"key":"e_1_2_8_158_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802172"},{"key":"e_1_2_8_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.09.004"},{"key":"e_1_2_8_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.02.009"},{"key":"e_1_2_8_161_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101560050001"},{"key":"e_1_2_8_162_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.25.695"},{"key":"e_1_2_8_163_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900584"},{"key":"e_1_2_8_164_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200800229"},{"key":"e_1_2_8_165_2","doi-asserted-by":"publisher","DOI":"10.1039\/b802248h"},{"key":"e_1_2_8_166_2","unstructured":"N. P. Kurumbang K. Liou J. K. Sohng J. Appl. Microbiol.2009; DOI:"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbic.200900779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.200900779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:28:45Z","timestamp":1760290125000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.200900779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,27]]},"references-count":167,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,5,3]]}},"alternative-id":["10.1002\/cbic.200900779"],"URL":"https:\/\/doi.org\/10.1002\/cbic.200900779","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,27]]},"assertion":[{"value":"2009-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}