{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:18:15Z","timestamp":1791091095826,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2011,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ion\u2010channel function can be modified in various ways. For example, numerous studies have shown that currents through voltage\u2010gated ion channels are affected by pore block or modification of voltage dependence of activation\/inactivation. Recent experiments performed on various ion channels show that allosteric modulation is an important mechanism for affecting channel function. For instance, in K<jats:sub>Ca<\/jats:sub>2 (formerly SK) channels, the prototypic \u201cblocker\u201d apamin prevents conduction by an allosteric mechanism, while TRPV1 channels are prevented from closing by a tarantula toxin, DkTx, through an interaction with residues located away from the selectivity filter. The recent evidence, therefore, suggests that in several ion channels, the region around the outer mouth of the pore is rich in binding sites and could be exploited therapeutically. These discoveries also suggest that the pharmacological vocabulary should be adapted to define these various actions.<\/jats:p>","DOI":"10.1002\/cbic.201100236","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T12:01:44Z","timestamp":1309521704000},"page":"1808-1812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ion\u2010Channel Modulators: More Diversity Than Previously Thought"],"prefix":"10.1002","volume":"12","author":[{"given":"S\u00e9bastien","family":"Dilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil V.","family":"Marrion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Li\u00e9geois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Seutin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04707"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.01.013"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2199"},{"key":"e_1_2_6_5_2","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161208785777423"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.09.022"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.10.026"},{"key":"e_1_2_6_9_2","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.37.23195"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)89487-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(97)00034-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308070200"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607213200"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-895X(25)10594-4","volume":"45","author":"Grissmer S.","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(95)79915-5"},{"key":"e_1_2_6_17_2","unstructured":"\u00a0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.114.4.551"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002490100147"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90276-J"},{"key":"e_1_2_6_21_2","unstructured":"\u00a0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1081\/RRS-120014604"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02381-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200609684"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb929"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66914-5"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.90.1.27"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2448877"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90156-0"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90157-2"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.91.3.335"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051656d"},{"key":"e_1_2_6_33_2","first-page":"572","volume":"40","author":"Hurst R. S.","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.42.24776"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90104-3"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716527"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.110072"},{"key":"e_1_2_6_38_2","unstructured":"\u00a0"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.11.025"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705979"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.302.3.1176"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00067-3"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3522"},{"key":"e_1_2_6_44_2","unstructured":"\u00a0"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17086.x"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701004"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi980929k"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.052"},{"key":"e_1_2_6_49_2","unstructured":"\u00a0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2169"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.012"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756360500210989"},{"key":"e_1_2_6_53_2","unstructured":"S.Dilly C.Lamy J.\u2010F.Li\u00e9geois V.Seutin in oral communication presented in the Spring Meeting of the Belgian Society ofFundamentalandClinicalPhysiologyandPharmacology (Ed.: ActaPhysiologica 678 O\u201010) Universit\u00e9 Libre de Bruxelles Brussels 2010."},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1623"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3609"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbic.201100236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201100236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:33:34Z","timestamp":1760286814000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.201100236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,8,16]]}},"alternative-id":["10.1002\/cbic.201100236"],"URL":"https:\/\/doi.org\/10.1002\/cbic.201100236","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"2011-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}