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The synthesis of several new pyrrolidine analogues substituted at the nitrogen or \u03b1\u2010carbon atom with alkyl chains of different lengths suggested an interpretation of the inhibition data and led to the discovery of two new GCase inhibitors at sub\u2010micromolar concentration. In the piperidine iminosugar series, two N\u2010alkylated derivatives were found to rescue the residual GCase activity in N370S\/RecNcil mutated human fibroblasts (among which one up to 1.5\u2010fold). This study provides the starting point for the identification of new compounds in the treatment of Gaucher disease.<\/jats:p>","DOI":"10.1002\/cbic.201500292","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T11:25:40Z","timestamp":1440761140000},"page":"2054-2064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Human Acid \u03b2\u2010Glucosidase Inhibition by Carbohydrate Derived Iminosugars: Towards New Pharmacological Chaperones for Gaucher Disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Camilla","family":"Parmeggiani","sequence":"first","affiliation":[{"name":"Department of Chemistry \u201cUgo Schiff\u201d University of Florence  Via della Lastruccia 3-13 50019 Sesto Fiorentino Italy"},{"name":"CNR-INO U.O.S. 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