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An interesting subgroup comprises the cyclodepsipeptide synthetases from fungi synthesizing cyclohexa\u2010 and cyclo\u2010octadepsipeptides with antibacterial, anthelmintic, insecticidal, and anticancer properties; some are marketed drugs. We exploit the modularity of these highly homologous synthetases by fusing the hydroxy\u2010acid\u2010activating module of PF1022 synthetase with the amino\u2010acid\u2010activating modules of enniatin and beauvericin synthetase, thus yielding novel hybrid synthetases. The artificial synthetases expressed in <jats:italic>Escherichia coli<\/jats:italic> and the fungus <jats:italic>Aspergillus niger<\/jats:italic> yielded new cyclodepsipeptides, thus paving the way for the exploration of these derivatives for their bioactivity.<\/jats:p>","DOI":"10.1002\/cbic.201500649","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T15:04:27Z","timestamp":1449759867000},"page":"283-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins"],"prefix":"10.1002","volume":"17","author":[{"given":"Sophia","family":"Zobel","sequence":"first","affiliation":[{"name":"Fachgebiet Biologische Chemie Institut f\u00fcr Chemie Technische Universit\u00e4t Berlin  Strasse des 17. 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