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The TEG\u2010modified G\u2010quadruplexes were stabilized significantly relative to unmodified DNA. In the presence of a TEG\u2010modified oligonucleotide that is capable of forming an intermolecular G\u2010quadruplex with a template containing a hu\u2010 man immunodeficiency virus\u20101 sequence, reverse transcription was inhibited by more than 70\u2009% relative to the reaction in the absence of the TEG\u2010modified oligonucleotide. Moreover, the TEG\u2010modified deoxythymidines protected the DNA oligonucleotide from degradation by various nucleases in human serum. 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