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SHIP2 has a confirmed role in opsismodysplasia, a disease of bone development, but also interacts with proteins involved in insulin signalling, cytoskeletal function (thus having an impact on endocytosis, adhesion, proliferation and apoptosis) and immune system function. The structure of three domains (constituting about 38\u2009% of the protein) is known. Inhibitors of SHIP2 activity have been designed to interact with the catalytic domain with sub\u2010micromolar IC<jats:sub>50<\/jats:sub> values: these come from a range of structural classes and have been shown to have in vivo effects consistent with SHIP2 inhibition. 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