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These agents have been shown to modify the gene\u2010expression pattern as well as cell signaling in tumor cells, but the underlying molecular mechanisms remain a matter of conjecture. Regulatory\/signaling proteins either of cytosolic or membrane origin abundantly contain intrinsically disordered sequences, the conformational pliability of which is pivotal in their biological functions. It is well known that chloroform (an anesthetic itself), trifluoroethanol, hexafluoroisopropanol, and related haloalcohols markedly affect the structure of disordered proteins and protein regions by inducing folding, misfolding, or even aggregation. Taking into consideration the physicochemical similarities and protein interaction modes of these volatile solvents and inhaled anesthetics, it is postulated that administration of these drugs can also modify the secondary structure of disordered protein segments. Accordingly, pharmacological effects of anesthetics may, at least in part, be mediated by conformational perturbations of intrinsic disorder\u2010based regulatory protein networks of cells.<\/jats:p>","DOI":"10.1002\/cbic.201700691","type":"journal-article","created":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T21:52:58Z","timestamp":1517781178000},"page":"895-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Un(f)told Story of General Anesthesia"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-2810","authenticated-orcid":false,"given":"Ferenc","family":"Zsila","sequence":"first","affiliation":[{"name":"Biomolecular Self-Assembly Group Institute of Materials and Environmental Chemistry Research Centre for Natural Sciences Hungarian Academy of Sciences  1117 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.073"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-015-0523-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31817f5b73"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer055"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001652"},{"key":"e_1_2_6_7_2","first-page":"13291","volume":"9","author":"Gu Q.","year":"2016","journal-title":"Int. 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