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Therefore, it is imperative to maintain an optimal nitric oxide concentration to ensure its biochemical function. A sustained nitric oxide releasing scaffold, which supports neuronal cell differentiation, as determined by morphometric analysis of neurite outgrowth, is described. Moreover, the effect of nitric oxide on the neuroblastoma cell line was also confirmed by immunofluorescent analysis of neuronal nuclear protein (NeuN), specific neuronal marker and neurofilament (NF) protein, which revealed a significant increase in their expression levels, in comparison with undifferentiated cells.<\/jats:p>","DOI":"10.1002\/cbic.201800065","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T03:50:38Z","timestamp":1522381838000},"page":"1127-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peptide\u2010Based Scaffold for Nitric Oxide Induced Differentiation of Neuroblastoma Cells"],"prefix":"10.1002","volume":"19","author":[{"given":"Hilal Ahmad","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Chemistry Centre for Nanoscience and Centre for Environmental Science and Engineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaiz A.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apurva","family":"Panjla","sequence":"additional","affiliation":[{"name":"Department of Chemistry Centre for Nanoscience and Centre for Environmental Science and Engineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Bioengineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-8109","authenticated-orcid":false,"given":"Sandeep","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Centre for Nanoscience and Centre for Environmental Science and Engineering Indian Institute of Technology Kanpur  Kanpur UP 208016 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5193"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199503000-00003"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00345.x"},{"key":"e_1_2_2_4_1","volume-title":"Nitric Oxide: Biology and Pathobiology","author":"Ignarro L. 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