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In recent years, insect\u2010associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a <jats:italic>Serratia<\/jats:italic> sp. within the midgut and salivary glands of <jats:italic>Anopheles stephensi<\/jats:italic> mosquitoes. The lipodepsipeptides, stephensiolides\u2005A\u2013K, have antibiotic activity and facilitate bacterial surface motility. Bioinformatic analyses indicate that the stephensiolides are ubiquitous in nature and are likely important for <jats:italic>Serratia<\/jats:italic> spp. colonization within mosquitoes, humans, and other ecological niches. Our results demonstrate the usefulness of probing insect\u2013microbiome interactions, enhance our understanding of the chemical ecology within <jats:italic>Anopheles<\/jats:italic> mosquitoes, and provide a secondary\u2010metabolite scaffold for further investigate of this complex relationship.<\/jats:p>","DOI":"10.1002\/cbic.201800124","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T22:22:00Z","timestamp":1524781320000},"page":"1590-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Discovery of Antimicrobial Lipodepsipeptides Produced by a <i>Serratia<\/i> sp. within Mosquito Microbiomes"],"prefix":"10.1002","volume":"19","author":[{"given":"Jack G.","family":"Ganley","sequence":"first","affiliation":[{"name":"Department of Chemistry Duke University  124 Science Drive Durham NC 27708-0346 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School  240 Longwood Avenue Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Ioerger","sequence":"additional","affiliation":[{"name":"Department of Computer Science Texas A&amp;M University  College Station TX 77843 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Sacchettini","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics Texas A&amp;M University  College Station TX 77843 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Clardy","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School  240 Longwood Avenue Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-8844","authenticated-orcid":false,"given":"Emily R.","family":"Derbyshire","sequence":"additional","affiliation":[{"name":"Department of Chemistry Duke University  124 Science Drive Durham NC 27708-0346 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,10]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160423"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.159"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol301043p"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402139"},{"key":"e_1_2_2_5_1","unstructured":"World Health Organization Vector-Borne Diseases 2016 www.who.int\/en\/news-room\/fact-sheets\/detail\/vector-borne-diseases."},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002742"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.05.001"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000423"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201618"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evu160"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-96"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01030-13"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-235"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NP00010C"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1270050309"},{"key":"e_1_2_2_16_1","first-page":"198","volume-title":"Spectrometric Identification of Organic Compounds","author":"Silverstein R. 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