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A tyrosine\u2010based short\u2010peptide amphiphile (sPA) was synthesized and observed to self\u2010assemble into \u03b2\u2010sheet\u2010like secondary structures. The self\u2010assembly of the designed sPA was modulated by application of different bioactive transition\u2010metal ions, as was confirmed by spectroscopic and microscopic techniques. These bioactive metal\u2010ion\u2010conjugated sPA hybrid structures were further used to develop antibacterial materials. As a result of the excellent antibacterial activity of zinc ions the growth of clinically relevant bacteria such as <jats:italic>Escherichia coli<\/jats:italic> was inhibited in the presence of zinc<jats:bold>\u22c5<\/jats:bold>sPA conjugate. Bacterial testing demonstrated that, due to high biocompatibility with bacterial cells, the designed sPA acted as a metal ion delivery agent and might therefore show great potential in locally addressing bacterial infections.<\/jats:p>","DOI":"10.1002\/cbic.201800220","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T11:03:44Z","timestamp":1526555024000},"page":"1630-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Transition Metal Ion\u2013Mediated Tyrosine\u2010Based Short\u2010Peptide Amphiphile Nanostructures Inhibit Bacterial Growth"],"prefix":"10.1002","volume":"19","author":[{"given":"Ramesh","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Chemical Science and Technology Dr. Harisingh Gour Central University  Sagar MP 470003 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Kumar\u2005Mishra","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Copenhagen  Universitetsparken 5 2100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Chemical Science and Technology Dr. Harisingh Gour Central University  Sagar MP 470003 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Vinayak","sequence":"additional","affiliation":[{"name":"Diatom Nanoengineering and Metabolism Lab (DNM) School of Applied Sciences Dr. Harisingh Gour Central University  Sagar MP 470003 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-3754","authenticated-orcid":false,"given":"Khashti","family":"Ballabh\u2005Joshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Chemical Science and Technology Dr. Harisingh Gour Central University  Sagar MP 470003 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20648"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja060573x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072699999"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/b915923c"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2633"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn2025397"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc03793a"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0775016"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00234F"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnma.201700129"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900134a"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010066"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5456.1245"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja026768w"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi5013673"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/la703833v"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201601548"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR06577A"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2015.05.020"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-014-9687-3"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46312-4_16"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705012"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200705012"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NJ04248E"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46312-4_8"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)0710382RFOTTT2.0.CO2"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cp50206f"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01256"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/o11-071"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.5.1438-1443.2002"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081059"},{"key":"e_1_2_2_31_1","first-page":"6","volume":"39","author":"Kotynia A.","year":"2013","journal-title":"Inorg. 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