{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:05:37Z","timestamp":1791018337397,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM128651"],"award-info":[{"award-number":["R35GM128651"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103440"],"award-info":[{"award-number":["GM103440"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000086","name":"Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["CHE-1808370"],"award-info":[{"award-number":["CHE-1808370"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL090699"],"award-info":[{"award-number":["HL090699"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2018,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Streptococcus pneumoniae<\/jats:italic> (pneumococcus) is a prevalent human pathogen responsible for a variety of diseases, including pneumonia, bacteremia, sepsis, meningitis and otitis media, with a death toll of &gt;22\u2009000 a year in the United States alone. Pneumococcus uses the competence regulon and its associated signaling peptide, the competence stimulating peptide (CSP), to initiate its attack on the host and establish an infection. In this work, we set out to: 1)\u2005develop a pan\u2010group quorum sensing inhibitor that could effectively interact with both the pneumococcus ComD1 and ComD2 receptors; and 2)\u2005evaluate the utility of dominant\u2010negative CSPs (dnCSPs) in attenuating pneumococcus infectivity. Our results highlight the potential of inhibiting the competence regulon as a therapeutic approach to combat pneumococcus infections.<\/jats:p>","DOI":"10.1002\/cbic.201800505","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T05:44:28Z","timestamp":1536817468000},"page":"2380-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Development of a Dominant Negative Competence\u2010Stimulating Peptide (dnCSP) that Attenuates <i>Streptococcus pneumoniae<\/i> Infectivity in a Mouse Model of Acute Pneumonia"],"prefix":"10.1002","volume":"19","author":[{"given":"Bimal","family":"Koirala","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  1664 North Virginia Street Reno Nevada 89557 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathobiology University of Illinois at Urbana\u2013Champaign  2001 South Lincoln Avenue Urbana Illinois 61802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gee W.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pathobiology University of Illinois at Urbana\u2013Champaign  2001 South Lincoln Avenue Urbana Illinois 61802 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-6782","authenticated-orcid":false,"given":"Yftah","family":"Tal\u2010Gan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  1664 North Virginia Street Reno Nevada 89557 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198545"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001517"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61204-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2011.12.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.02.088"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.501417.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112464599"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1072"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.11140"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02335.x"},{"key":"e_1_2_7_11_1","first-page":"1389","volume":"45","author":"Hava D. L.","year":"2002","journal-title":"Mol. Microbiol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05310.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012427"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3112115"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602974"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201602974"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.01.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuw009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01444"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00709-17"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00115"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.14.151"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666180518090705"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.20.6087-6090.1996"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002241"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00007"},{"key":"e_1_2_7_28_1","volume-title":"Fmoc Solid Phase Peptide Synthesis, Vol.\u2005222","author":"Chan W. C.","year":"2000"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01207.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0289-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.3.480"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00071-11"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbic.201800505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201800505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.201800505","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/cbic.201800505","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201800505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:40:59Z","timestamp":1760269259000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.201800505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":33,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2018,11,16]]}},"alternative-id":["10.1002\/cbic.201800505"],"URL":"https:\/\/doi.org\/10.1002\/cbic.201800505","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"2018-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}