{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:57Z","timestamp":1786977357262,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2627-M-009-002"],"award-info":[{"award-number":["MOST 107-2627-M-009-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2019,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A general strategy for the diverse synthesis of ten disaccharide aminoglycosides, including natural 2\u2010trehalosamine (\n                    <jats:bold>1<\/jats:bold>\n                    ), 3\u2010trehalosamine (\n                    <jats:bold>2<\/jats:bold>\n                    ), 4\u2010trehalosamine (\n                    <jats:bold>3<\/jats:bold>\n                    ), and neotrehalosyl 3,3\u2032\u2010diamine (\n                    <jats:bold>8<\/jats:bold>\n                    ) and synthetic aminoglycosides\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    , has been developed. The aminoglycoside compounds feature different anomeric configurations and numbers of amino groups. The key step for the synthesis was the glycosylation coupling of a stereodirecting donor with a configuration\u2010stable TMS glycoside acceptor. Either the donor or acceptor could be substituted with an azido group. The aminoglycosides prepared in the present study were characterized by 1D and 2D NMR spectroscopy.\n                  <\/jats:p>","DOI":"10.1002\/cbic.201800656","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T03:28:43Z","timestamp":1542079723000},"page":"287-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1\u2032\u2010Disaccharide Aminoglycosides"],"prefix":"10.1002","volume":"20","author":[{"given":"Yen\u2010Chu","family":"Lu","sequence":"first","affiliation":[{"name":"Applied Chemistry Department National Chiao Tung University  1001, University Road 300 Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumik","family":"Mondal","sequence":"additional","affiliation":[{"name":"Applied Chemistry Department National Chiao Tung University  1001, University Road 300 Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Chi","family":"Wang","sequence":"additional","affiliation":[{"name":"Applied Chemistry Department National Chiao Tung University  1001, University Road 300 Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Academia Sinica, Nankang  128, Academia Road Sec. 2 Nankang 300 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-1072","authenticated-orcid":false,"given":"Kwok\u2010Kong Tony","family":"Mong","sequence":"additional","affiliation":[{"name":"Applied Chemistry Department National Chiao Tung University  1001, University Road 300 Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","first-page":"896","volume":"87","author":"Arcamone F.","year":"1957","journal-title":"Gazz. 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