{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:48Z","timestamp":1786977288135,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-06122"],"award-info":[{"award-number":["RGPIN-2016-06122"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nicotinamide and pyridine\u2010containing conjugates have attracted a lot of attention in research as they have found use in a wide range of applications including as redox flow batteries and calcium channel blockers, in biocatalysis, and in metabolism. The interesting redox character of the compounds\u2019 pyridine\/dihydropyridine system allows them to possess very similar characteristics to the natural chiral redox agents NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH, even mimicking their functions. There has been considerable interest in designing and synthesizing NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH mimetics with similar redox properties. In this research, three nicotinamide conjugates were designed, synthesized, and characterized. Molecular structures obtained through X\u2010ray crystallography were obtained for two of the conjugates, thereby providing more detail on the bonding and structure of the compounds. The compounds were then further evaluated for biochemical properties, and it was found that one of the conjugates possessed similar functions and characteristics to the natural NADH. This compound was evaluated in the active enzyme, enoate reductase; like NADH, it was shown to help reduce the C=C double bond of three substrates and even outperformed the natural coenzyme. Kinetic data are reported.\n                  <\/jats:p>","DOI":"10.1002\/cbic.201800661","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T10:03:00Z","timestamp":1543572180000},"page":"838-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase"],"prefix":"10.1002","volume":"20","author":[{"given":"Natashya","family":"Falcone","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  200 College Street Toronto M5S 3E5 Ontario Canada"},{"name":"Department of Physical and Environmental Sciences University of Toronto Scarborough  1065 Military Trail Scarborough M1C 1A4 Ontario 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