{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:35:23Z","timestamp":1783035323367,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2020,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synthesis and characterization of three new platinum complexes, with 3,5\u2010diacetyl\u20101,2,4\u2010triazole bis(4\u2010<jats:italic>N<\/jats:italic>\u2010isopropylthiosemicarbazone) as a ligand, are reported. The specific conditions under which solvent coordination takes place are reported and the X\u2010ray structure of the complex with one solvent molecule of dimethyl sulfoxide is resolved. Analysis of the reactivity of these platinum compounds aids in finding the best solution profile for biological investigations. Then, the interactions of the complexes with biological models, such as calf\u2010thymus DNA, are studied by using UV spectroscopy and tracking the changes in electrophoretic mobility produced in the supercoiled plasmid DNA model. Initial screening of these potential antitumoral compounds indicates possible selective antitumoral action.<\/jats:p>","DOI":"10.1002\/cbic.201900545","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T02:54:40Z","timestamp":1574218480000},"page":"1226-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-0656","authenticated-orcid":false,"given":"Ana I.","family":"Matesanz","sequence":"first","affiliation":[{"name":"Inorganic Chemistry Department Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.","family":"Herrero","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-2511","authenticated-orcid":false,"given":"Eva J.","family":"Faraco","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-8951","authenticated-orcid":false,"given":"Leticia","family":"Cubo","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-9542","authenticated-orcid":false,"given":"Adoracion G.","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Inorganic Chemistry Department Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"},{"name":"Institute for Advanced Research in Chemical Sciences (IAdChem) Universidad Aut\u00f3noma de Madrid  Ciudad Universitaria de Cantoblanco 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jinorgbio.2012.06.002","volume":"114","author":"Quiroga A. G.","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/ic202036c","volume":"51","author":"Messori L.","year":"2012","journal-title":"Inorg. Chem."},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1039\/c0dt00838a","volume":"39","author":"Huxley M.","year":"2010","journal-title":"Dalton Trans."},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"12627","DOI":"10.1021\/ic502373n","volume":"53","author":"Herrera J. M.","year":"2014","journal-title":"Inorg. Chem."},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1039\/C7QI00446J","volume":"5","author":"Matesanz A. I.","year":"2018","journal-title":"Inorg. Chem. Front."},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cct.2003.11.004","volume":"248","author":"Quiroga A. G.","year":"2004","journal-title":"Coord. Chem. Rev."},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1021\/acs.inorgchem.9b00126","volume":"58","author":"Cabrera S.","year":"2019","journal-title":"Inorg. Chem."},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"12538","DOI":"10.1039\/c2dt31199b","volume":"41","author":"Matesanz A. I.","year":"2012","journal-title":"Dalton Trans."},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1039\/c2cp41090g","volume":"14","author":"Pinter B.","year":"2012","journal-title":"Phys. Chem. Chem. Phys."},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1080\/00958972.2014.900664","volume":"67","author":"Tavares T. T.","year":"2014","journal-title":"J. Coord. Chem."},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/acs.inorgchem.8b02996","volume":"58","author":"Romero M. J.","year":"2019","journal-title":"Inorg. Chem."},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jinorgbio.2014.04.017","volume":"138","author":"Matesanz A. I.","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"14768","DOI":"10.1002\/chem.201303341","volume":"19","author":"Patra M.","year":"2013","journal-title":"Chem. Eur. J."},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"14896","DOI":"10.1039\/C5DT01196E","volume":"44","author":"Marzo T.","year":"2015","journal-title":"Dalton Trans."},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ccr.2014.08.002","volume":"284","author":"Medici S.","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1039\/c2sc20627g","volume":"3","author":"Casini A.","year":"2012","journal-title":"Chem. Sci."},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1039\/C4CS00063C","volume":"43","author":"Kapdi A. R.","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/cr040704h","volume":"106","author":"Timerbaev A. R.","year":"2006","journal-title":"Chem. Rev."},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/9780470370612.ch6","volume-title":"Drug\u2013DNA Interactions","author":"Nakamoto K.","year":"2008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-9861(02)00202-3","volume":"403","author":"Haq I.","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.370979","volume":"203","author":"Cohen G. L.","year":"1979","journal-title":"Science"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.171340","volume":"5","author":"Echeverri M.","year":"2018","journal-title":"Royal Soc. Open Sci."},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","volume":"116","author":"Johnstone T. C.","year":"2016","journal-title":"Chem. Rev."},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jinorgbio.2006.08.012","volume":"101","author":"Quiroga A. G.","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2967\/jnumed.117.191965","volume":"58","author":"Lamichhane N.","year":"2017","journal-title":"J. Nucl. Med."},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10610270600902340","volume":"19","author":"Brandt C. D.","year":"2007","journal-title":"Supramol. Chem."},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"10668","DOI":"10.3390\/molecules161210668","volume":"16","author":"Reis C. M. D.","year":"2011","journal-title":"Molecules"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201900545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.201900545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201900545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:55:33Z","timestamp":1760291733000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.201900545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4,17]]}},"alternative-id":["10.1002\/cbic.201900545"],"URL":"https:\/\/doi.org\/10.1002\/cbic.201900545","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]},"assertion":[{"value":"2019-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}