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Herein, we report the synthesis of a multifunctional implant based on ovalbumin (OVA) as a carrier capable of synergistically delivering a photothermal transducing agent (polydopamine, PDA) to tumors. The formation of PDA was achieved by utilizing the basicity of OVA, whereas the formation of the hydrogel implant was achieved through the in vitro\/in vivo near\u2010infrared (NIR) laser\u2010induced hyperthermia of PDA. The as\u2010prepared PDA@OVA implant exhibits high photothermal conversion efficiency (38.7\u2009%). Once implanted in vivo, the OVA\u2010based implant shows great versatility in the treatment of malignant tumors. Furthermore, a chemotherapeutic (doxorubicin, DOX) and a contrast agent (iohexol), dispersed in the OVA solution in advance, can also be firmly entrapped in the hydrogel along with the hydrogel formation. It is anticipated that the multifunctional OVA\u2010based implant, not showing any obvious toxicity to healthy tissue, could be a promising system for synergistic cancer treatment.<\/jats:p>","DOI":"10.1002\/cbic.201900556","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T07:02:37Z","timestamp":1571122957000},"page":"865-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Injectable Ovalbumin\u2010Based Composite Implant for Photothermal Tumor Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Science University of Shanghai for Science and Technology  No. 334 Jungong Road Shanghai 200093 P. R. 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