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Of the tools available for intracellular enhancement of SO\n                    <jats:sub>2<\/jats:sub>\n                    levels, most suffer from poor cell permeability and a lack of control over SO\n                    <jats:sub>2<\/jats:sub>\n                    release. We report 1,2\u2010cyclic sulfite diesters as a new class of reliable SO\n                    <jats:sub>2<\/jats:sub>\n                    donors that dissociate in buffer through nucleophilic displacement to produce SO\n                    <jats:sub>2<\/jats:sub>\n                    with tunable release profiles. We provide data in support of the suitability of these SO\n                    <jats:sub>2<\/jats:sub>\n                    donors to enhance intracellular SO\n                    <jats:sub>2<\/jats:sub>\n                    levels more efficiently than sodium bisulfite, the most commonly used SO\n                    <jats:sub>2<\/jats:sub>\n                    donor for cellular studies.\n                  <\/jats:p>","DOI":"10.1002\/cbic.201900614","type":"journal-article","created":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T21:48:30Z","timestamp":1573422510000},"page":"1201-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO\n                    <sub>2<\/sub>\n                    ) 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