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A prostate\u2010specific membrane antigen (PSMA)\u2010targeting ligand, armed with both an organotrifluoroborate and a metal\u2010chelator (DOTA), was designed to optionally afford <jats:sup>18<\/jats:sup>F\u2010, <jats:sup>64<\/jats:sup>Cu\u2010 or <jats:sup>177<\/jats:sup>Lu\u2010labeled products that were injected into mice bearing prostate cancer (LNCaP) xenografts. PET\/CT images and ex vivo biodistribution data show high, specific tumor uptake irrespective of which radionuclide is used, thereby demonstrating a new approach to combining, in a single molecule, <jats:sup>18<\/jats:sup>F\u2010labeling capabilities for PET imaging with radiometalation for potential imaging and therapeutic applications.<\/jats:p>","DOI":"10.1002\/cbic.201900632","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:04:24Z","timestamp":1571263464000},"page":"943-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Toward <sup>18<\/sup>F\u2010Labeled Theranostics: A Single Agent that Can Be Labeled with <sup>18<\/sup>F, <sup>64<\/sup>Cu, or <sup>177<\/sup>Lu"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-7902","authenticated-orcid":false,"given":"Mathieu 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