{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:56:24Z","timestamp":1788404184191,"version":"build-2803163510"},"reference-count":210,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM118157"],"award-info":[{"award-number":["R35 GM118157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI101171"],"award-info":[{"award-number":["R01 AI101171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2020,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sequestration of the essential nutrient iron from bacterial invaders that colonize the vertebrate host is a central feature of nutritional immunity and the \u201cfight over transition metals\u201d at the host\u2010pathogen interface. The iron quota for many bacterial pathogens is large, as iron enzymes often make up a significant share of the metalloproteome. Iron enzymes play critical roles in respiration, energy metabolism, and other cellular processes by catalyzing a wide range of oxidation\u2010reduction, electron transfer, and oxygen activation reactions. In this Concept article, we discuss recent insights into the diverse ways that bacterial pathogens acquire this essential nutrient, beyond the well\u2010characterized tris\u2010catecholate Fe<jats:sup>III<\/jats:sup> complexes, in competition and cooperation with significant host efforts to cripple these processes. We also discuss pathogen strategies to adapt their metabolism to less\u2010than\u2010optimal iron concentrations, and briefly speculate on what might be an integrated adaptive response to the concurrent limitation of both iron and zinc in the infected host.<\/jats:p>","DOI":"10.1002\/cbic.201900778","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:25:12Z","timestamp":1584404712000},"page":"1955-1967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Iron Acquisition by Bacterial Pathogens: Beyond Tris\u2010Catecholate Complexes"],"prefix":"10.1002","volume":"21","author":[{"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry Indiana University  Bloomington IN 47405-7102 USA"},{"name":"Department of Molecular and Cellular Biochemistry Indiana University  Bloomington IN 47405-7102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambuddha","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indiana University  Bloomington IN 47405-7102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-1620","authenticated-orcid":false,"given":"David P.","family":"Giedroc","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indiana University  Bloomington IN 47405-7102 USA"},{"name":"Department of Molecular and Cellular Biochemistry Indiana University  Bloomington IN 47405-7102 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00146d"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09265"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08300"},{"key":"e_1_2_10_4_1","unstructured":"\u00a0"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr0603699"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.02.011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240130021018"},{"key":"e_1_2_10_8_1","unstructured":"\u00a0"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713008114"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.032066599"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00764-16"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0211-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13158"},{"key":"e_1_2_10_14_1","unstructured":"\u00a0"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-004-0739-4"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.571562"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00112F"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-006-9070-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12052"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.007757"},{"key":"e_1_2_10_21_1","unstructured":"\u00a0"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00091-17"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05577.x"},{"key":"e_1_2_10_24_1","unstructured":"\u00a0"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180902"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.587071"},{"key":"e_1_2_10_27_1","unstructured":"\u00a0"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100410108"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.330365"},{"key":"e_1_2_10_30_1","unstructured":"\u00a0"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09375"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630018100"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/b906679a"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.10.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.3.405"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo400258w"},{"key":"e_1_2_10_37_1","unstructured":"\u00a0"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00849-5"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(90)90229-F"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.13.3944-3955.1994"},{"key":"e_1_2_10_41_1","unstructured":"\u00a0"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394390-3.00002-1"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19757"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/4931"},{"key":"e_1_2_10_45_1","unstructured":"\u00a0"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27888-0"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01042"},{"key":"e_1_2_10_48_1","unstructured":"\u00a0"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00013-15"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00075"},{"key":"e_1_2_10_51_1","unstructured":"\u00a0"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11508-y"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2012-02993"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201311159"},{"key":"e_1_2_10_55_1","unstructured":"\u00a0"},{"key":"e_1_2_10_56_2","first-page":"67","volume":"35","author":"Braun V.","year":"1998","journal-title":"Met. Ions Biol. Syst."},{"key":"e_1_2_10_57_2","first-page":"5","volume":"55","author":"Hantke K.","year":"1990","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011018"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2019.10.008"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi500729h"},{"key":"e_1_2_10_61_1","unstructured":"\u00a0"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172924"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00117-11"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b04557"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.097865"},{"key":"e_1_2_10_66_1","volume":"8","author":"Boer M.","year":"2019","journal-title":"Elife"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-7-1647"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.19.5359-5364.2000"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004380050718"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42270"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00986"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0522027"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00203"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi201517h"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01062-10"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0357661"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.143.1.246-255.1980"},{"key":"e_1_2_10_78_1","first-page":"1479","volume":"135","author":"Meyer J. M.","year":"1989","journal-title":"J. Gen. Microbiol."},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10823"},{"key":"e_1_2_10_80_1","unstructured":"\u00a0"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.54.1.126-132.1986"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt20254b"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071451"},{"key":"e_1_2_10_84_1","unstructured":"\u00a0"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.159.1.341-347.1984"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic034862n"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1dt11804h"},{"key":"e_1_2_10_88_1","unstructured":"\u00a0"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00624"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.171.4.1811-1816.1989"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913991116"},{"key":"e_1_2_10_92_1","unstructured":"\u00a0"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00417-15"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/121.2.129"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.98.3.1142-1150.1969"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6953-6961.2003"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00446867"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01135388"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.11.005"},{"key":"e_1_2_10_100_1","unstructured":"\u00a0"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.3.1"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1984.247.1.E21"},{"key":"e_1_2_10_103_1","unstructured":"\u00a0"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00666-09"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00478-10"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520829113"},{"key":"e_1_2_10_107_1","unstructured":"\u00a0"},{"key":"e_1_2_10_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb09463.x"},{"key":"e_1_2_10_109_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.065607-0"},{"key":"e_1_2_10_110_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12148"},{"key":"e_1_2_10_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00075-06"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1259329"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01028-09"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(96)00198-5"},{"key":"e_1_2_10_115_1","unstructured":"H. Pi J.\u2005D. Helmann 2018."},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12221"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12118"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.14.4714-4729.2004"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45941"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.10.008"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708747114"},{"key":"e_1_2_10_122_1","unstructured":"\u00a0"},{"key":"e_1_2_10_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00557-13"},{"key":"e_1_2_10_124_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00057"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.52.1.263-270.1986"},{"key":"e_1_2_10_126_1","unstructured":"\u00a0"},{"key":"e_1_2_10_127_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00874-16"},{"key":"e_1_2_10_128_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05064-11"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-8-1985"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00658"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv049"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MT00097B"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00745"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1987.tb02241.x"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00626-06"},{"key":"e_1_2_10_136_1","unstructured":"\u00a0"},{"key":"e_1_2_10_137_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503896200"},{"key":"e_1_2_10_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2016.05.005"},{"key":"e_1_2_10_139_1","unstructured":"\u00a0"},{"key":"e_1_2_10_140_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00052-06"},{"key":"e_1_2_10_141_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01987.x"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12739"},{"key":"e_1_2_10_143_1","unstructured":"\u00a0"},{"key":"e_1_2_10_144_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-006-9051-x"},{"key":"e_1_2_10_145_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.342"},{"key":"e_1_2_10_146_1","unstructured":"\u00a0"},{"key":"e_1_2_10_147_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00738-13"},{"key":"e_1_2_10_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.027"},{"key":"e_1_2_10_149_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2017.1420451"},{"key":"e_1_2_10_150_1","author":"Dauner M.","year":"2019","journal-title":"ChemBioChem"},{"key":"e_1_2_10_151_1","unstructured":"\u00a0"},{"key":"e_1_2_10_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.11.014"},{"key":"e_1_2_10_153_2","author":"Huang X.","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw1629"},{"key":"e_1_2_10_155_1","unstructured":"\u00a0"},{"key":"e_1_2_10_156_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449"},{"key":"e_1_2_10_157_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03695.x"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1891"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220341110"},{"key":"e_1_2_10_161_1","unstructured":"\u00a0"},{"key":"e_1_2_10_162_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja307974e"},{"key":"e_1_2_10_163_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3096416"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC03487J"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00250"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00044H"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.03.013"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-549"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-126"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-003-0517-8"},{"key":"e_1_2_10_171_1","unstructured":"\u00a0"},{"key":"e_1_2_10_172_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.05103-11"},{"key":"e_1_2_10_173_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.26.100172.001035"},{"key":"e_1_2_10_174_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00047083"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.056978-0"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/fty009"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps184043"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.6.1473-1479.1998"},{"key":"e_1_2_10_179_1","unstructured":"\u00a0"},{"key":"e_1_2_10_180_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03113.x"},{"key":"e_1_2_10_181_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01919-07"},{"key":"e_1_2_10_182_1","unstructured":"\u00a0"},{"key":"e_1_2_10_183_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01478"},{"key":"e_1_2_10_184_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13424"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01650-14"},{"key":"e_1_2_10_186_1","unstructured":"\u00a0"},{"key":"e_1_2_10_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.007"},{"key":"e_1_2_10_188_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b01173"},{"key":"e_1_2_10_189_1","author":"Chandrangsu P.","year":"2019","journal-title":"Mol. Microbiol."},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13927"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00051-18"},{"key":"e_1_2_10_192_1","unstructured":"\u00a0"},{"key":"e_1_2_10_193_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1018"},{"key":"e_1_2_10_194_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16765-9"},{"key":"e_1_2_10_195_1","unstructured":"\u00a0"},{"key":"e_1_2_10_196_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01281-17"},{"key":"e_1_2_10_197_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718382115"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00082-17"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003733"},{"key":"e_1_2_10_200_1","unstructured":"\u00a0"},{"key":"e_1_2_10_201_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11951"},{"key":"e_1_2_10_202_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92464"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300046"},{"key":"e_1_2_10_204_1","unstructured":"\u00a0"},{"key":"e_1_2_10_205_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1020"},{"key":"e_1_2_10_206_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004483"},{"key":"e_1_2_10_207_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00341A"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.19.6701-6707.2005"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00708-6"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8074665"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbic.201900778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201900778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.201900778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.201900778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:20:27Z","timestamp":1760275227000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.201900778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":210,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7,16]]}},"alternative-id":["10.1002\/cbic.201900778"],"URL":"https:\/\/doi.org\/10.1002\/cbic.201900778","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]},"assertion":[{"value":"2019-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}